Evidence map›Paper›PMID 33230702›Full record

ArticleInflammopharmacology2021

Oral administration of dermatan sulphate reduces venous thrombus formation in vivo: potential use as a formulation for venous thromboembolism.

Simone A Osborne, Paul P Masci, Qianyun Sharon Du, Robyn A Daniel, Kirthi Desilva, Luis Vitetta, Kong-Nan Zhao, Robert B Seymour

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Inflammopharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 75% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Simone A OsborneCSIRO, Agriculture and Food, Queensland Bioscience Precinct, 306 Carmody Road, St Lucia, QLD, 4067, Australia. Simone.Osborne@csiro.au.
Paul P MasciCentre for Clinical Research, The University of Queensland, Royal Brisbane and Women's Hospital Campus, Herston, Brisbane, QLD, 4029, Australia.
Qianyun Sharon DuCentre for Clinical Research, The University of Queensland, Royal Brisbane and Women's Hospital Campus, Herston, Brisbane, QLD, 4029, Australia.
Robyn A DanielCSIRO, Agriculture and Food, Queensland Bioscience Precinct, 306 Carmody Road, St Lucia, QLD, 4067, Australia.
Kirthi DesilvaCSIRO, Agriculture and Food, 671 Sneydes Road, Werribee, VIC, 3030, Australia.
Luis VitettaMedlab Clinical Ltd., 66 McCauley Street, Alexandria, NSW, 2015, Australia.
Kong-Nan ZhaoCentre for Clinical Research, The University of Queensland, Royal Brisbane and Women's Hospital Campus, Herston, Brisbane, QLD, 4029, Australia.ORCID http://orcid.org/0000-0001-8076-063X
Robert B SeymourCSIRO, Agriculture and Food, Queensland Bioscience Precinct, 306 Carmody Road, St Lucia, QLD, 4067, Australia.
Commonwealth Scientific and Industrial Research Organisation · AUTranslational Research Institute · AUThe University of Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dermatan sulphate (DS) is a sulphated polysaccharide that displays complexity in constituent sulphated disaccharides and interacts with proteins and signalling molecules to modulate numerous biological processes, including inhibition of the coagulation cascade and regulation of blood clotting and fibrinolysis. This study shows the antithrombotic and anticoagulant effects of DS prepared from bovine collagen waste liquor following oral and intravenous administrations in a deep vein thrombosis (DVT) rabbit model. In vitro, the prothrombin time, activated partial thromboplastin time, and thrombin citrated plasma clotting assays revealed that bovine DS had strong antithrombotic and anticoagulant effects comparable to low-molecular-weight heparin [Clexane

Indexed as

Administration, OralAnimalsAnticoagulantsCattleCollagenDermatan SulfateDisease Models, AnimalEnoxaparinMaleRabbitsThrombelastographyVenous ThromboembolismVenous ThrombosisAnticoagulantsCollagenDermatan SulfateEnoxaparinAntithromboticBovine collagen waste liquorDermatan sulphateIn vivo DVT modelOral anticoagulantVenous thromboembolism

Identifiers

PMID33230702
OpenAlexW3106578501

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.