Evidence map›Paper›PMID 33230634›Full record

ArticleBiological trace element research2021

Amyotrophic Lateral Sclerosis After Exposure to Manganese from Traditional Medicine Procedures in Kenya.

Elin Roos, Sebastian K T S Wärmländer, Jeremy Meyer, Sabrina B Sholts, Jüri Jarvet, Astrid Gräslund, Per M Roos

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PubMed Full text at PMC Publisher
In one paragraph

Article in Biological trace element research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
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  7. Article
  8. Metals in ALS TDP-43 Pathology.International journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 4 countries.

Elin RoosDepartment of Global Public Health, Karolinska Institutet, 171 77, Stockholm, Sweden. elin.roos@ki.se.ORCID http://orcid.org/0000-0002-8275-2702
Sebastian K T S WärmländerDepartment of Biochemistry and Biophysics, Stockholm University, 106 91, Stockholm, Sweden.
Jeremy MeyerUnit for Surgical Research, Medical School of Geneva, University of Geneva, 120511, 14, Genève, Switzerland.
Sabrina B SholtsDepartment of Anthropology, National Museum of Natural History, Smithsonian Institution, 370 12, Washington D.C, USA.
Jüri JarvetDepartment of Biochemistry and Biophysics, Stockholm University, 106 91, Stockholm, Sweden.
Astrid GräslundDepartment of Biochemistry and Biophysics, Stockholm University, 106 91, Stockholm, Sweden.
Per M RoosInstitute of Environmental Medicine, Karolinska Institutet, 171 77, Stockholm, Sweden.
Stockholm University · SEKarolinska Institutet · SESmithsonian Institution · USUniversity of Geneva · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by motor neuron loss and widespread muscular atrophy. Despite intensive investigations on genetic and environmental factors, the cause of ALS remains unknown. Recent data suggest a role for metal exposures in ALS causation. In this study we present a patient who developed ALS after a traditional medical procedure in Kenya. The procedure involved insertion of a black metal powder into several subcutaneous cuts in the lower back. Four months later, general muscle weakness developed. Clinical and electrophysiological examinations detected widespread denervation consistent with ALS. The patient died from respiratory failure less than a year after the procedure. Scanning electron microscopy and X-ray diffraction analyses identified the black powder as potassium permanganate (KMnO4). A causative relationship between the systemic exposure to KMnO4 and ALS development can be suspected, especially as manganese is a well-known neurotoxicant previously found to be elevated in cerebrospinal fluid from ALS patients. Manganese neurotoxicity and exposure routes conveying this toxicity deserve further attention.

Indexed as

Amyotrophic Lateral SclerosisNeurodegenerative DiseasesHumansKenyaManganeseMedicine, TraditionalManganeseAmyotrophic lateral sclerosisManganeseNeurodegenerationPotassium permanganateTraditional medicine

Identifiers

PMID33230634
PMCPMC8360856
OpenAlexW3109928239

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.