ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2021
Association Between Brain Volumes and Patterns of Physical Activity in Community-Dwelling Older Adults.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Effects of Hearing Intervention on Physical Activity Measured by Accelerometry: A Secondary Analysis of the ACHIEVE Study.Journal of the American Geriatrics Society · 2025Trial
- The association of vitamin D supplementation and serum vitamin D levels with physical activity in older adults: Results from a randomized trial.Journal of the American Geriatrics Society · 2023Trial
- Article
- Real-world walking patterns are associated with regional brain atrophy and white matter lesions in middle-aged and older people: a Watch Walk-UK Biobank study.GeroScience · 2026Article
- Accelerometry-derived activity fragmentation as a predictor of brain atrophy and disability progression in multiple sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2026Article
- Associations between physical activity and brain structure in a large community cohort.Scientific reports · 2025Article
- Purpose in life and accelerometer-measured physical activity among older adults.Psychology & health · 2025Article
- The Role of Cognitive Reserve in Protecting Cerebellar Volumes of Older Adults with mild Cognitive Impairment.Cerebellum (London, England) · 2024Article
- Impact of distinct cognitive domains on gait variability in individuals with mild cognitive impairment and dementia.Experimental brain research · 2024Article
- Differences in Daily Physical Activity by Alzheimer's Risk Markers Among Older Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Correlates of life course physical activity in participants of the Baltimore longitudinal study of aging.Aging cell · 2024Article
- Exercise-Related Physical Activity Relates to Brain Volumes in 10,125 Individuals.Journal of Alzheimer's disease : JAD · 2024Article
- Wrist-Worn Accelerometry, Aging, and Gait Speed in the Baltimore Longitudinal Study of Aging.Journal of aging and physical activity · 2023Article
- Objectively Measured Patterns of Daily Physical Activity and Phenotypic Frailty.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- Comparison of Accelerometry-Based Measures of Physical Activity: Retrospective Observational Data Analysis Study.JMIR mHealth and uHealth · 2022Observational
- Assessment of Physical Activity in Adults Using Wrist Accelerometers.Epidemiologic reviews · 2022Review
- Daily Physical Activity Patterns as a Window on Cognitive Diagnosis in the Baltimore Longitudinal Study of Aging (BLSA).Journal of Alzheimer's disease : JAD · 2022Article
- Early manifestation of gait alterations in the Tg2576 mouse model of Alzheimer's disease.GeroScience · 2021Article
- Physical activity complexity, cognition, and risk of cognitive impairment and dementia in the Baltimore Longitudinal Study of Aging.Alzheimer's & dementia (New York, N. Y.)Article
- Directionality between cognitive function and daily physical activity patterns.Alzheimer's & dementia (New York, N. Y.)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
backgroundLarger brain volumes are often associated with more free-living physical activity (PA) in cognitively normal older adults. Yet, whether greater brain volumes are associated with more favorable (less fragmented) PA patterns, and whether this association is stronger than with total PA, remains unknown.
methodsBrain magnetic resonance imaging and wrist-worn accelerometer data were collected in 301 participants (mean age = 77 [SD = 7] years, 59% women) enrolled in the Baltimore Longitudinal Study of Aging. Linear regression models were fit to examine whether brain volumes (cc) were cross-sectionally associated with: (a) total daily PA minutes and (b) activity fragmentation (mean number of PA bouts / total PA minutes × 100). Sensitivity analyses were conducted by adjusting for counterpart PA variables (eg, fragmentation covariate included in the PA minutes model).
resultsGreater white matter volumes in the parietal and temporal lobes were associated with higher daily PA minutes (2.6 [SE = 1.0] and 3.8 [0.9] min/day, respectively; p < .009 for both) after adjusting for demographics, behavioral factors, medical conditions, gait speed, apolipoprotein E e4 status, and intracranial volume. Greater temporal white matter volume was associated with lower fragmentation (-0.16% [0.05], p = .003). In sensitivity analyses, observed associations between brain volumes and daily PA minutes remained significant while associations with fragmentation no longer remained significant.
conclusionsOur results suggest white matter brain structure in cognitively normal older adults is associated with the total amount of PA and, to a lesser extent, the PA accumulation patterns. More work is needed to elucidate the longitudinal relationship between brain structure and function and PA patterns with aging.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.