Evidence map›Paper›PMID 33230535›Full record

ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2021

Physical Performance During the Menopausal Transition and the Role of Physical Activity.

Dmitriy Bondarev, Taija Finni, Katja Kokko, Urho M Kujala, Pauliina Aukee, Vuokko Kovanen, Eija K Laakkonen, Sarianna Sipilä

Registry-linked trialAbstract read
In one paragraph

Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07472205 (Randomized Clinical Trial of the Effects of a 12-Week Foot and Ankle Strengthening Program on Physical Function and Quality of Life in Menopausal Women), which is not on this map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07472205 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Randomized Clinical Trial of the Effects of a 12-Week Foot and Ankle Strengthening Program on Physical Function and Quality of Life in Menopausal Women

TypeinterventionalSponsorUniversity of MalagaRan2026 to 2027Enrolled70ConditionsMenopause, Musculoskeletal Function, Physical FunctionArmsFoot and ankle exercise program
3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Trial
  2. The effect of quercetin and citrulline on cycling time trial performance.Journal of the International Society of Sports Nutrition · 2024
    Trial
  3. Article
  4. Article
  5. Article
  6. Article
  7. "I know it will make me feel better": a grounded theory of sea gazing and well-being for women in midlife.International journal of qualitative studies on health and well-being · 2025
    Article
  8. Article
  9. Body composition and functional capacity as determinants of physical activity in middle-aged and older adults: a cross-sectional analysis.European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Aging and Adiposity-Focus on Biological Females at Midlife and Beyond.International journal of molecular sciences · 2024
    Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Dmitriy BondarevGerontology Research Center and Faculty of Sport and Health Sciences, University of Jyväskylä, Finland.ORCID 0000-0001-8497-8898
Taija FinniNeuromuscular Research Center, Faculty of Sport and Health Sciences, University of Jyväskylä, Finland.
Katja KokkoGerontology Research Center and Faculty of Sport and Health Sciences, University of Jyväskylä, Finland.
Urho M KujalaFaculty of Sport and Health Sciences, University of Jyväskylä, Finland.
Pauliina AukeeDepartment of Obstetrics and Gynecology, Pelvic Floor Research and Therapy Unit, Central Finland Central Hospital, Jyväskylä, Finland.
Vuokko KovanenFaculty of Sport and Health Sciences, University of Jyväskylä, Finland.
Eija K LaakkonenGerontology Research Center and Faculty of Sport and Health Sciences, University of Jyväskylä, Finland.
Sarianna SipiläGerontology Research Center and Faculty of Sport and Health Sciences, University of Jyväskylä, Finland.ORCID 0000-0001-5934-7728

Funding

Marie Curie 675003
6 · The paper itself

Abstract

backgroundTo examine longitudinal changes in physical performance during the menopausal transition and the role of physical activity (PA) in these changes.

methodsBased on follicle-stimulating hormone levels and bleeding diaries, women (47-55 years) were classified as early (n = 89) and late perimenopausal (n = 143) and followed prospectively until postmenopausal status, with mean duration of 17.5 and 13.8 months, respectively. Physical performance was measured by handgrip force, knee extension torque, vertical jumping height, maximal walking speed, and 6-minute walking distance. Physical activity was self-reported and categorized as inactive, low, medium, and high. Longitudinal associations of menopausal status, physical performance, and related changes with PA level were analyzed using generalized estimation equations adjusted for duration of hormonal therapy.

resultsA significant decline over the menopausal transition in handgrip force (-2.1%, 95% CI -3.8 to -0.4), knee extension torque (-2.6%, 95% CI -4.5 to -0.8), and vertical jumping height (-2.6%, 95% CI -4.2 to -1.1) and a significant increase in 6-minute walking distance (2.1%, 95% CI 1.4 to 2.7) were observed in the total sample. A significant interaction of PA by time was observed in handgrip force and in vertical jumping height. High PA women had greater increase in handgrip strength but greater decline in vertical jumping height than medium, low, and inactive women (all p ≤ .001).

conclusionsBoth early and late perimenopausal women show decline in muscle strength and power during the transition to postmenopause. Physical activity seems to influence physical performance during the menopausal transition but understanding the benefits of PA requires interventional studies.

Indexed as

ExercisePhysical Functional PerformanceAnthropometryBiomarkersFemaleFollicle Stimulating HormoneHand StrengthHumansLongitudinal StudiesMenopauseMiddle AgedMuscle StrengthProspective StudiesTorqueWalkingBiomarkersFollicle Stimulating HormoneLongitudinal changesMenopauseMuscle powerMuscle strengthWalking

Identifiers

PMID33230535
PMCPMC8361353

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.