Evidence map›Paper›PMID 33230470›Full record

ArticleMolecular therapy. Nucleic acids2020

Downregulation of MicroRNA-222 Reduces Insulin Resistance in Rats with PCOS by Inhibiting Activation of the MAPK/ERK Pathway

Hong Ye, Xiu-Juan Liu, Yan Hui, Yang-Huan Liang, Cai-Hong Li, Qiong Wan

RetractedOpen access · goldAbstract readRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy. Nucleic acids, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
5.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Dysregulated Liver Metabolism and Polycystic Ovarian Syndrome.International journal of molecular sciences · 2023
    Review
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Hong YeDepartment of Obstetrics and Gynecology, The First Clinical Medical College, China Three Gorges University, Yichang 443003, Hubei Province, China.
Xiu-Juan LiuDepartment of Obstetrics and Gynecology, The First Clinical Medical College, China Three Gorges University, Yichang 443003, Hubei Province, China.
Yan HuiDepartment of Obstetrics and Gynecology, The First Clinical Medical College, China Three Gorges University, Yichang 443003, Hubei Province, China.
Yang-Huan LiangDepartment of Obstetrics and Gynecology, The First Clinical Medical College, China Three Gorges University, Yichang 443003, Hubei Province, China.
Cai-Hong LiDepartment of Obstetrics and Gynecology, The First Clinical Medical College, China Three Gorges University, Yichang 443003, Hubei Province, China.
Qiong WanDepartment of Obstetrics and Gynecology, The First Clinical Medical College, China Three Gorges University, Yichang 443003, Hubei Province, China.
China Three Gorges University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Polycystic ovary syndrome (PCOS), characterized by the dysfunction of endocrine metabolism, is a common disease among women. Insulin (INS) resistance (IR) is considered as an obstruction to effective PCOS treatment. Here, we aimed to explore the mechanism by which microRNA-222 (miR-222) affects IR in PCOS via

Indexed as

insulin resistanceMAPK/ERK pathwaymicroRNA-222polycystic ovary syndromePten

Identifiers

PMID33230470
PMCPMC7593506
OpenAlexW3041320592

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.