Evidence map›Paper›PMID 33230464›Full record

ArticleMolecular therapy. Nucleic acids2020

Exosome-Shuttled circSHOC2 from IPASs Regulates Neuronal Autophagy and Ameliorates Ischemic Brain Injury via the miR-7670-3p/SIRT1 Axis.

Wanghao Chen, Hong Wang, Zhihan Zhu, Jia Feng, Lukui Chen

Open access · goldAbstract read
In one paragraph

Article in Molecular therapy. Nucleic acids, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
86citing papers in PubMed, 1 pooled it
7.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

86 citing papers in PubMed, 1 synthesis or guideline pooled it, 130 citations in OpenAlex.

  1. Pooled it
  2. Review
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  4. Article
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  6. Article
  7. Review
  8. Article
  9. Article
  10. Nanobiotechnologies for stroke treatment.Nanomedicine (London, England) · 2025
    Review
  11. Review
  12. Review
  13. Extracellular Vesicles for Disease Treatment.International journal of nanomedicine · 2025
    Review
  14. Review
  15. Article
  16. Alterations ofCurrent Alzheimer research · 2025
    Article
  17. Review
  18. Review
  19. Review
  20. Article

26 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Wanghao ChenMedical School of Southeast University, Nanjing 210009, P.R. China.
Hong WangMedical School of Southeast University, Nanjing 210009, P.R. China.
Zhihan ZhuMedical School of Southeast University, Nanjing 210009, P.R. China.
Jia FengMedical School of Southeast University, Nanjing 210009, P.R. China.
Lukui ChenMedical School of Southeast University, Nanjing 210009, P.R. China.
Southeast University · CNTCM-Intigrated Cancer Center of Southern Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of the present study was to investigate the neuroprotective roles and mechanisms of the circular RNA circSHOC2 in ischemic-preconditioned astrocyte-derived exosomes (IPAS-EXOs) against ischemic stroke. We established an ischemia model based on oxygen glucose deprivation (OGD)

Indexed as

autophagycircRNAischemic-preconditioned astrocyte-derived exosomesMCAOmiR-7670-3pneuroprotectionOGDSIRT1

Identifiers

PMID33230464
PMCPMC7581834
OpenAlexW3088118809

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.