ArticleNature neuroscience2021
An offset ON-OFF receptive field is created by gap junctions between distinct types of retinal ganglion cells.
Article in Nature neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A meta-analysis of single-nucleus expression quantitative trait loci linking genetic risk to brain disorders.Nature genetics · 2026Pooled it
- Photomapping electrically coupled networks of the mature thalamus and cortex.Science advances · 2026Article
- Population-level geometric filtering generates motion-coherence selectivity in the retina.Science advances · 2026Article
- Temporally segregated functions for Gfi1 in the development and maintenance of direction selectivity in the vertebrate retina.Current biology : CB · 2026Article
- Photomapping electrically coupled networks of the mature thalamus and cortex.bioRxiv : the preprint server for biology · 2026Article
- Thrombospondin-1 proteomimetic polymers exhibit anti-angiogenic activity in a neovascular age-related macular degeneration mouse model.Science advances · 2023Article
- Classical center-surround receptive fields facilitate novel object detection in retinal bipolar cells.Nature communications · 2022Article
- High-density electrode recordings reveal strong and specific connections between retinal ganglion cells and midbrain neurons.Nature communications · 2022Article
- Unified classification of mouse retinal ganglion cells using function, morphology, and gene expression.Cell reports · 2022Article
- Retinal patterns and the cellular repertoire of neuropsin (Opn5) retinal ganglion cells.The Journal of comparative neurology · 2022Article
- Distinct inhibitory pathways control velocity and directional tuning in the mouse retina.Current biology : CB · 2022Article
- Feedback from retinal ganglion cells to the inner retina.PloS one · 2021Article
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2 authors.
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Abstract
In the vertebrate retina, the location of a neuron's receptive field in visual space closely corresponds to the physical location of synaptic input onto its dendrites, a relationship called the retinotopic map. We report the discovery of a systematic spatial offset between the ON and OFF receptive subfields in F-mini-ON retinal ganglion cells (RGCs). Surprisingly, this property does not come from spatially offset ON and OFF layer dendrites, but instead arises from a network of electrical synapses via gap junctions to RGCs of a different type, the F-mini-OFF. We show that the asymmetric morphology and connectivity of these RGCs can explain their receptive field offset, and we use a multicell model to explore the effects of receptive field offset on the precision of edge-location representation in a population. This RGC network forms a new electrical channel combining the ON and OFF feedforward pathways within the output layer of the retina.
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