ArticleNature neuroscience2021
Auditory activity is diverse and widespread throughout the central brain of Drosophila.
Article in Nature neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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41 citing papers in PubMed.
- Protocol for simultaneous in vivo two-photon imaging and locomotion quantification during olfactory stimulation and pharmacology in walking Drosophila.STAR protocols · 2026Article
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- High-speed whole-brain imaging in Drosophila.Nature communications · 2026Article
- Linking structure and function: biological insights from fly connectomes.Nature methods · 2025Article
- Prominent involvement of acetylcholine dynamics in stable olfactory representation across the Drosophila brain.Nature communications · 2025Article
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- Sexually-dimorphic neurons in theResearch square · 2025Article
- Sexually-dimorphic neurons in thebioRxiv : the preprint server for biology · 2025Article
- Inferring neural population codes forProceedings of the National Academy of Sciences of the United States of America · 2025Article
- TWINKLE: An open-source two-photon microscope for teaching and research.bioRxiv : the preprint server for biology · 2025Article
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- BIFROST: A method for registering diverse imaging datasets of theProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Nonnegative matrix factorization for analyzing state dependent neuronal network dynamics in calcium recordings.Scientific reports · 2024Article
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- The fly connectome reveals a path to the effectome.Nature · 2024Article
- Neuronal wiring diagram of an adult brain.Nature · 2024Article
- Building and integrating brain-wide maps of nervous system function in invertebrates.Current opinion in neurobiology · 2024Review
- Neural correlates of individual facial recognition in a social wasp.bioRxiv : the preprint server for biology · 2024Article
- Network Statistics of the Whole-Brain Connectome ofbioRxiv : the preprint server for biology · 2024Article
- From connectome to effectome: learning the causal interaction map of the fly brain.bioRxiv : the preprint server for biology · 2024Article
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4 authors.
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Abstract
Sensory pathways are typically studied by starting at receptor neurons and following postsynaptic neurons into the brain. However, this leads to a bias in analyses of activity toward the earliest layers of processing. Here, we present new methods for volumetric neural imaging with precise across-brain registration to characterize auditory activity throughout the entire central brain of Drosophila and make comparisons across trials, individuals and sexes. We discover that auditory activity is present in most central brain regions and in neurons responsive to other modalities. Auditory responses are temporally diverse, but the majority of activity is tuned to courtship song features. Auditory responses are stereotyped across trials and animals in early mechanosensory regions, becoming more variable at higher layers of the putative pathway, and this variability is largely independent of ongoing movements. This study highlights the power of using an unbiased, brain-wide approach for mapping the functional organization of sensory activity.
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