Evidence map›Paper›PMID 33230304›Full record

ArticleNature biomedical engineering2021

Transdermal microneedles for the programmable burst release of multiple vaccine payloads.

Khanh T M Tran, Tyler D Gavitt, Nicholas J Farrell, Eli J Curry, Arlind B Mara, Avi Patel, Lindsey Brown, Shawn Kilpatrick, Roxana Piotrowska, Neha Mishra and 2 more

Abstract read
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In one paragraph

Article in Nature biomedical engineering, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers.

0numbers the graph read from it
0cells of the map it votes in
88citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

88 citing papers in PubMed.

  1. Review
  2. Programmable Paracrine-Mimetic Microneedle System for Temporal Regulation of Cardiac Repair.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Microneedle-Assisted Cell Delivery and Therapy.Research (Washington, D.C.) · 2026
    Review
  10. Review
  11. Article
  12. Review
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Enhancing vaccine stability in transdermal microneedle platforms.Drug delivery and translational research · 2025
    Review
  20. Article

28 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Khanh T M TranDepartment of Biomedical Engineering, University of Connecticut, Storrs, CT, USA.
Tyler D GavittDepartment of Pathobiology and Veterinary Science, University of Connecticut, Storrs, CT, USA.ORCID http://orcid.org/0000-0002-3014-4166
Nicholas J FarrellDepartment of Biomedical Engineering, University of Connecticut, Storrs, CT, USA.ORCID http://orcid.org/0000-0003-0395-5702
Eli J CurryDepartment of Biomedical Engineering, University of Connecticut, Storrs, CT, USA.ORCID http://orcid.org/0000-0001-8396-3037
Arlind B MaraDepartment of Pathobiology and Veterinary Science, University of Connecticut, Storrs, CT, USA.ORCID http://orcid.org/0000-0001-9823-5243
Avi PatelDepartment of Molecular and Cell Biology, University of Connecticut, Storrs, CT, USA.
Lindsey BrownDepartment of Pathobiology and Veterinary Science, University of Connecticut, Storrs, CT, USA.
Shawn KilpatrickAdvanced Science Research Center, Graduate Center, City University of New York, New York, NY, USA.
Roxana PiotrowskaAdvanced Science Research Center, Graduate Center, City University of New York, New York, NY, USA.
Neha MishraDepartment of Pathobiology and Veterinary Science, University of Connecticut, Storrs, CT, USA.
Steven M SzczepanekDepartment of Pathobiology and Veterinary Science, University of Connecticut, Storrs, CT, USA.ORCID http://orcid.org/0000-0002-1782-3375
Thanh D NguyenDepartment of Biomedical Engineering, University of Connecticut, Storrs, CT, USA. nguyentd@uconn.edu.ORCID http://orcid.org/0000-0003-0813-4807

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Repeated bolus injections are associated with higher costs and poor compliance and can hinder the implementation of global immunization campaigns. Here, we report the development and preclinical testing of patches of transdermal core-shell microneedles-which were fabricated by the micromoulding and alignment of vaccine cores and shells made from poly(lactic-co-glycolic acid) with varying degradability kinetics-for the preprogrammed burst release of vaccine payloads over a period of a few days to more than a month from a single administration. In rats, microneedles loaded with a clinically available vaccine (Prevnar-13) against the bacterium Streptococcus pneumoniae induced immune responses that were similar to immune responses observed after multiple subcutaneous bolus injections, and led to immune protection against a lethal bacterial dose. Microneedle patches delivering preprogrammed doses may offer an alternative strategy to prophylactic and therapeutic protocols that require multiple injections.

Indexed as

NeedlesVaccinesAdministration, CutaneousAnimalsDrug Delivery SystemsRatsVaccinationVaccines

Identifiers

PMID33230304

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.