Evidence map›Paper›PMID 33230300›Full record

SynthesisNature genetics2020

Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals.

Praveen Surendran, Elena V Feofanova, Najim Lahrouchi, Ioanna Ntalla, Savita Karthikeyan, James Cook, Lingyan Chen, Borbala Mifsud, Chen Yao, Aldi T Kraja and 276 more

Erratum issuedOpen access · bronzeAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Nature genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 116 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
116citing papers in PubMed, 11 pooled it
16.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

116 citing papers in PubMed, 11 syntheses or guidelines pooled it, 233 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
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  6. Pooled it
  7. Pooled it
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  9. Pooled it
  10. Pooled it
  11. Pooled it
  12. Trial
  13. Rare, Damaging DNA Variants inCirculation. Genomic and precision medicine · 2021
    Trial
  14. Article
  15. Article
  16. Article
  17. Article
  18. Integrative Genomic Analyses IdentifybioRxiv : the preprint server for biology · 2026
    Article
  19. Review
  20. Article

56 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

286 authors at 20 institutions in 27 countries.

Praveen Surendran *British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Elena V Feofanova *Human Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.ORCID http://orcid.org/0000-0003-1428-7199
Najim Lahrouchi *Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Ioanna Ntalla *William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Savita Karthikeyan *British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
James CookDepartment of Biostatistics, University of Liverpool, Liverpool, UK.
Lingyan ChenBritish Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Borbala MifsudWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Chen YaoFramingham Heart Study, Framingham, MA, USA.
Aldi T KrajaDivision of Statistical Genomics, Department of Genetics and Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, MO, USA.
James H CartwrightWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Jacklyn N HellwegeDivision of Epidemiology, Department of Medicine, Institute for Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Tennessee Valley Healthcare System (626)/Vanderbilt University, Nashville, TN, USA.
Ayush GiriDivision of Epidemiology, Department of Medicine, Institute for Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Tennessee Valley Healthcare System (626)/Vanderbilt University, Nashville, TN, USA.
Vinicius TraganteDepartment of Cardiology, Division Heart & Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
Gudmar ThorleifssondeCODE genetics/Amgen, Inc, Reykjavik, Iceland.
Dajiang J LiuInstitute of Personalized Medicine, Penn State College of Medicine, Hershey, PA, USA.
Bram P PrinsBritish Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Isobel D StewartMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK.
Claudia P CabreraWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
James M EalesDivision of Cardiovascular Sciences, Faculty of Medicine, Biology and Health, University of Manchester, Manchester, UK.
Artur AkbarovDivision of Cardiovascular Sciences, Faculty of Medicine, Biology and Health, University of Manchester, Manchester, UK.
Paul L AuerJoseph J Zilber School of Public Health, University of Wisconsin, Milwaukee, WI, USA.
Lawrence F BielakDepartment of Epidemiology, University of Michigan, Ann Arbor, MI, USA.
Joshua C BisCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Vickie S BraithwaiteMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK.
Jennifer A BrodyCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
E Warwick DawDivision of Statistical Genomics, Department of Genetics and Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, MO, USA.
Helen R WarrenWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Fotios DrenosDepartment of Life Sciences, College of Health and Life Sciences, Brunel University London, London, UK.
Sune Fallgaard NielsenDepartment of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.
Jessica D FaulSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.
Eric B FaumanInternal Medicine Research Unit, Pfizer, Cambridge, MA, USA.
Cristiano FavaDepartment of Medicine, University of Verona, Verona, Italy.
Teresa FerreiraThe Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK.
Christopher N FoleyBritish Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Nora FranceschiniDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.
He GaoDepartment of Epidemiology and Biostatistics, MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.
Olga GiannakopoulouWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Franco GiulianiniDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Daniel F GudbjartssondeCODE genetics/Amgen, Inc, Reykjavik, Iceland.
Xiuqing GuoInstitute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Sarah E HarrisCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
Aki S HavulinnaCentre for Genomic and Experimental Medicine, University of Edinburgh, Edinburgh, UK.
Anna HelgadottirdeCODE genetics/Amgen, Inc, Reykjavik, Iceland.
Jennifer E HuffmanMRC Human Genetics Unit, IGMM, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, UK.
Shih-Jen HwangPopulation Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Stavroula KanoniWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Jukka KonttoDepartment of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland.
Martin G LarsonBoston University and National Heart, Lung and Blood Institute Framingham Heart Study, Framingham, MA, USA.
Ruifang Li-GaoDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.
Jaana LindströmDepartment of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland.
Luca A LottaMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK.
Yingchang LuThe Charles Bronfman Institute for Personalized Medicine at Mount Sinai, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Jian'an LuanMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK.
Anubha MahajanWellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Giovanni MalerbaDepartment of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.
Nicholas G D MascaDepartment of Cardiovascular Sciences, University of Leicester, Leicester, UK.
Hao MeiDepartment of Data Science, School of Population Health, University of Mississippi Medical Center, Jackson, MS, USA.
Cristina MenniDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.
Dennis O Mook-KanamoriDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.
David Mosen-AnsorenaDepartment of Epidemiology and Biostatistics, MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.
Martina Müller-NurasyidInstitute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Guillaume ParéDepartment of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.
Dirk S PaulBritish Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Markus PerolaDepartment of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland.
Alaitz PovedaDepartment of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Skåne University Hospital Malmö, Malmö, Sweden.
Rainer RauramaaKuopio Research Institute of Exercise Medicine, Kuopio, Finland.
Melissa RichardInstitute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
Tom G RichardsonMRC Integrative Epidemiology Unit (IEU), Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
Nuno SepúlvedaDepartment of Infection Biology, Faculty of Tropical and Infectious Diseases, London School of Hygiene & Tropical Medicine, London, UK.
Xueling SimDepartment of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
Albert V SmithIcelandic Heart Association, Kopavogur, Iceland.
Jennifer A SmithDepartment of Epidemiology, University of Michigan, Ann Arbor, MI, USA.
James R StaleyBritish Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Alena StanákováUniversity of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.
Patrick SulemdeCODE genetics/Amgen, Inc, Reykjavik, Iceland.
Sébastien ThériaultPopulation Health Research Institute, McMaster University, Hamilton, Ontario, Canada.
Unnur ThorsteinsdottirdeCODE genetics/Amgen, Inc, Reykjavik, Iceland.
Stella TrompetDepartment of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands.
Tibor V VargaDepartment of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Skåne University Hospital Malmö, Malmö, Sweden.
Digna R Velez EdwardsVanderbilt Genetics Institute, Vanderbilt Epidemiology Center, Department of Obstetrics and Gynecology, Vanderbilt University Medical Center, Tennessee Valley Health Systems VA, Nashville, TN, USA.
Giovanni VeronesiResearch Center in Epidemiology and Preventive Medicine, Department of Medicine and Surgery, University of Insubria, Varese, Italy.
Stefan WeissInterfaculty Institute for Genetics and Functional Genomics, University Medicine and University of Greifswald, Greifswald, Germany.
Sara M WillemsMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK.
Jie YaoInstitute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Robin YoungBritish Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Bing YuHuman Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA.
Weihua ZhangDepartment of Epidemiology and Biostatistics, MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.
Jing-Hua ZhaoBritish Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Wei ZhaoDepartment of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA, USA.
Wei ZhaoDepartment of Epidemiology, University of Michigan, Ann Arbor, MI, USA.
Evangelos EvangelouDepartment of Epidemiology and Biostatistics, MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.
Stefanie AeschbacherDivision of Cardiology, University Hospital, Basel, Switzerland.
Eralda AsllanajInstitute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Stefan BlankenbergDZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.
Lori L BonnycastleMedical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, MD, USA.
Jette Bork-JensenNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Ivan BrandslundDepartment of Clinical Biochemistry, Lillebaelt Hospital, Vejle, Denmark.
Peter S BraundDepartment of Cardiovascular Sciences, University of Leicester, Leicester, UK.
Stephen BurgessBritish Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Kelly ChoMassachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.
Cramer ChristensenMedical Department, Lillebaelt Hospital, Vejle, Denmark.
John ConnellUniversity of Dundee, Ninewells Hospital & Medical School, Dundee, UK.
Renée de MutsertDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.
Anna F DominiczakInstitute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland, UK.
Marcus DörrDZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.
Gudny EiriksdottirIcelandic Heart Association, Kopavogur, Iceland.
Aliki-Eleni FarmakiDepartment of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, Greece.
J Michael GazianoMassachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.
Niels GrarupNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Megan L GroveHuman Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.
Göran HallmansDepartment of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.
Torben HansenNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Christian T HaveNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Gerardo HeissDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.
Marit E JørgensenSteno Diabetes Center, Copenhagen, Gentofte, Denmark.
Pekka JousilahtiDepartment of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland.
Eero KajantieDepartment of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland.
Mihir KamatBritish Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
AnneMari KäräjämäkiDepartment of Primary Health Care, Vaasa Central Hospital, Vaasa, Finland.
Fredrik KarpeOxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
Heikki A KoistinenDepartment of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland.
Csaba P KovesdyNephrology Section, Memphis VA Medical Center, Memphis, TN, USA.
Kari KuulasmaaDepartment of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland.
Tiina LaatikainenDepartment of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland.
Lars LannfeltDepartment of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden.
I-Te LeeDivision of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
Wen-Jane LeeDepartment of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan.
LifeLines Cohort Study
Allan LinnebergCenter for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark.
Lisa W MartinGeorge Washington University School of Medicine and Health Sciences, Washington DC, USA.
Marie MoitryDepartment of Public health, Strasbourg University Hospital, University of Strasbourg, Strasbourg, France.
Girish NadkarniThe Charles Bronfman Institute for Personalized Medicine at Mount Sinai, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Matt J NevilleOxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
Colin N A PalmerMedical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee, Scotland, UK.
George J PapanicolaouEpidemiology Branch, NHLBI, Bethesda, MD, USA.
Oluf PedersenNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
James PetersBritish Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Neil PoulterInternational Centre for Circulatory Health, Imperial College London, London, UK.
Asif RasheedCentre for Non-Communicable Diseases, Karachi, Pakistan.
Katrine L RasmussenDepartment of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.
N William RaynerWellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Reedik MägiInstitute of Genomics, University of Tartu, Tartu, Estonia.
Frida RenströmDepartment of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Skåne University Hospital Malmö, Malmö, Sweden.
Rainer RettigDZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.
Jacques RossouwDivision of Cardiovascular Sciences, NHLBI, Bethesda, MD, USA.
Pamela J SchreinerDivision of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, USA.
Peter S SeverNational Heart and Lung Institute, Imperial College London, London, UK.
Emil L SigurdssonDepartment of Family Medicine, University of Iceland, Reykjavik, Iceland.
Tea SkaabyCenter for Clinical Research and Disease Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark.
Yan V SunDepartment of Epidemiology, Emory University Rollins School of Public Health, Department of Biomedical Informatics, Emory University School of Medicine, Atlanta, GA, USA.
Johan SundstromDepartment of Medical Sciences, Uppsala University, Uppsala, Sweden.
Gudmundur ThorgeirssondeCODE genetics/Amgen, Inc, Reykjavik, Iceland.
Tõnu EskoInstitute of Genomics, University of Tartu, Tartu, Estonia.
Elisabetta TrabettiDepartment of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.
Philip S TsaoVA Palo Alto Health Care System, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Tiinamaija TuomiFolkhälsan Research Centre, Helsinki, Finland.
Stephen T TurnerDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA.
Ioanna TzoulakiDepartment of Epidemiology and Biostatistics, MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.
Ilonca VaartjesJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, University of Utrecht, University of Utrecht, Utrecht, the Netherlands.
Anne-Claire VergnaudDepartment of Epidemiology and Biostatistics, MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.
Cristen J WillerDepartment of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI, USA.
Peter W F WilsonAtlanta VAMC and Emory Clinical Cardiovascular Research Institute, Atlanta, GA, USA.
Daniel R WitteDepartment of Public Health, Aarhus University, Aarhus, Denmark.
Ekaterina Yonova-DoingBritish Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
He ZhangDepartment of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI, USA.
Naheed AliyaInternational Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.
Peter AlmgrenDepartment of Medicine, Lund University, Malmö, Sweden.
Philippe AmouyelUniv Lille, U1167 - RID-AGE - Facteurs de Risque et Déterminants Moléculaires des Maladies Liées au Vieillissement, Lille, France.
Folkert W AsselbergsDepartment of Cardiology, Division Heart & Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
Michael R BarnesWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Alexandra I BlakemoreDepartment of Life Sciences, College of Health and Life Sciences, Brunel University London, London, UK.
Michael BoehnkeDepartment of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
Michiel L BotsJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, University of Utrecht, University of Utrecht, Utrecht, the Netherlands.
Erwin P BottingerThe Charles Bronfman Institute for Personalized Medicine at Mount Sinai, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Julie E BuringDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.
John C ChambersDepartment of Epidemiology and Biostatistics, MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.
Yii-Der Ida ChenInstitute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Rajiv ChowdhuryBritish Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
David ConenPopulation Health Research Institute, McMaster University, Hamilton, Ontario, Canada.
Adolfo CorreaJackson Heart Study, Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.
George Davey SmithMRC Integrative Epidemiology Unit (IEU), Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
Rudolf A de BoerUniversity of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, the Netherlands.
Ian J DearyCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
George DedoussisDepartment of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, Greece.
Panos DeloukasWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Emanuele Di AngelantonioBritish Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Paul ElliottDepartment of Epidemiology and Biostatistics, MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.
EPIC-CVD
EPIC-InterAct
Stephan B FelixDZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.
Jean FerrièresDepartment of Cardiology and Department of Epidemiology, INSERM UMR 1027, Toulouse University Hospital, Toulouse, France.
Ian FordRobertson Centre for Biostatistics, University of Glasgow, Glasgow, UK.
Myriam FornageInstitute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
Paul W FranksDepartment of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Skåne University Hospital Malmö, Malmö, Sweden.
Stephen FranksInstitute of Reproductive & Developmental Biology, Imperial College London, London, UK.
Philippe FrossardCentre for Non-Communicable Diseases, Karachi, Pakistan.
Giovanni GambaroDivision of Nephrology, Department of Medicine, University of Verona, Verona, Italy.
Tom R GauntMRC Integrative Epidemiology Unit (IEU), Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
Leif GroopDepartment of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Malmö, Sweden.
Vilmundur GudnasonIcelandic Heart Association, Kopavogur, Iceland.
Tamara B HarrisLaboratory of Epidemiology and Population Sciences, National Institute of Aging, Bethesda, MD, USA.
Caroline HaywardMRC Human Genetics Unit, IGMM, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, UK.
Branwen J HennigMRC Unit The Gambia at London School of Hygiene & Tropical Medicine, Banjul, Gambia.
Karl-Heinz HerzigInstitute of Biomedicine, Medical Research Center (MRC), University of Oulu, and University Hospital Oulu, Oulu, Finland.
Erik IngelssonDepartment of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Jaakko TuomilehtoDepartment of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland.
Marjo-Riitta JärvelinDepartment of Life Sciences, College of Health and Life Sciences, Brunel University London, London, UK.
J Wouter JukemaDepartment of Cardiology, Leiden University Medical Center, Leiden, the Netherlands.
Sharon L R KardiaDepartment of Epidemiology, University of Michigan, Ann Arbor, MI, USA.
Frank KeeCentre for Public Health, Queens University Belfast, Belfast, UK.
Jaspal S KoonerNational Institute for Health Research (NIHR) Imperial Biomedical Research Centre, Imperial College London, London, UK.
Charles KooperbergFred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, WA, USA.
Lenore J LaunerLaboratory of Epidemiology and Population Sciences, National Institute of Aging, Bethesda, MD, USA.
Lars LindDepartment of Medical Sciences, Uppsala University, Uppsala, Sweden.
Ruth J F LoosThe Charles Bronfman Institute for Personalized Medicine at Mount Sinai, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Abdulla Al Shafi MajumderNational Institute of Cardiovascular Diseases, Sher-e-Bangla Nagar, Dhaka, Bangladesh.
Markku LaaksoDepartment of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.
Mark I McCarthyWellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Olle MelanderDepartment of Clinical Sciences Malmö, Lund University, Malmö, Sweden.
Karen L MohlkeDepartment of Genetics, University of North Carolina, Chapel Hill, NC, USA.
Alison D MurrayThe Institute of Medical Sciences, Aberdeen Biomedical Imaging Centre, University of Aberdeen, Aberdeen, UK.
Børge Grønne NordestgaardDepartment of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.
Marju Orho-MelanderDepartment of Clinical Sciences Malmö, Lund University, Malmö, Sweden.
Chris J PackardUniversity of Glasgow, Glasgow, UK.
Sandosh PadmanabhanInstitute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
Walter PalmasDepartment of Medicine, Columbia University Medical Center, New York, NY, USA.
Ozren PolasekDepartment of Public Health, University of Split School of Medicine, Split, Croatia.
David J PorteousCentre for Genomic and Experimental Medicine, Institute of Genetics & Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK.
Andrew M PrenticeMRC Unit The Gambia at London School of Hygiene & Tropical Medicine, Banjul, Gambia.
Michael A ProvinceDivision of Statistical Genomics, Department of Genetics and Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, MO, USA.
Caroline L ReltonMRC Integrative Epidemiology Unit (IEU), Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
Kenneth RiceDepartment of Biostatistics, University of Washington, Seattle, WA, USA.
Paul M RidkerDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Olov RolandssonDepartment of Public Health & Clinical Medicine, Umeå University, Umeå, Sweden.
Frits R RosendaalDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.
Jerome I RotterInstitute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Igor RudanCentre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Scotland, UK.
Veikko SalomaaDepartment of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland.
Nilesh J SamaniDepartment of Cardiovascular Sciences, University of Leicester, Leicester, UK.
Naveed SattarInstitute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland, UK.
Wayne H-H SheuDivision of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
Blair H SmithDivision of Population Health and Genomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK.
Nicole SoranzoNational Institute for Health Research (NIHR) Blood and Transplant Research Unit (BTRU) in Donor Health and Genomics at the University of Cambridge, Cambridge, UK.
Timothy D SpectorDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.
John M StarrCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
Sylvain SebertCenter for Life-Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland.
Kent D TaylorInstitute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Timo A LakkaKuopio Research Institute of Exercise Medicine, Kuopio, Finland.
Nicholas J TimpsonMRC Integrative Epidemiology Unit (IEU), Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
Martin D TobinNational Institute for Health Research Leicester Biomedical Research Centre, Leicester, UK.
Understanding Society Scientific Group
Pim van der HarstUniversity of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, the Netherlands.
Peter van der MeerUniversity of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, the Netherlands.
Vasan S RamachandranBoston University and National Heart, Lung and Blood Institute Framingham Heart Study, Framingham, MA, USA.
Niek VerweijUniversity Medical Center Groningen, Groningen, the Netherlands.
Jarmo VirtamoDepartment of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland.
Uwe VölkerInterfaculty Institute for Genetics and Functional Genomics, University Medicine and University of Greifswald, Greifswald, Germany.
David R WeirSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.
Eleftheria ZegginiWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.
Fadi J CharcharDepartment of Cardiovascular Sciences, University of Leicester, Leicester, UK.
Million Veteran Program
Nicholas J WarehamMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK.
Claudia LangenbergMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK.
Maciej TomaszewskiDivision of Cardiovascular Sciences, Faculty of Medicine, Biology and Health, University of Manchester, Manchester, UK.
Adam S ButterworthBritish Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Mark J CaulfieldWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
John DaneshBritish Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Todd L EdwardsDivision of Epidemiology, Department of Medicine, Institute for Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Tennessee Valley Healthcare System (626)/Vanderbilt University, Nashville, TN, USA.
Hilma HolmdeCODE genetics/Amgen, Inc, Reykjavik, Iceland.
Adriana M HungVA Tennessee Valley Healthcare System, Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt Center for Kidney Disease, Vanderbilt University Medical Center, Nashville, TN, USA.
Cecilia M LindgrenProgram in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Chunyu LiuBoston University School of Public Health, Boston, MA, USA.
Alisa K ManningDepartment of Medicine, Harvard Medical School, Boston, MA, USA.
Andrew P MorrisDepartment of Biostatistics, University of Liverpool, Liverpool, UK.
Alanna C MorrisonHuman Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.
Christopher J O'DonnellVA Boston Healthcare, Section of Cardiology and Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Bruce M PsatyCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Danish SaleheenBritish Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Kari StefanssondeCODE genetics/Amgen, Inc, Reykjavik, Iceland.
Eric BoerwinkleHuman Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.
Daniel I ChasmanDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0003-3357-0862
Daniel LevyBoston University and National Heart, Lung and Blood Institute Framingham Heart Study, Framingham, MA, USA.
Christopher Newton-ChehProgram in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Patricia B MunroeWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK. p.b.munroe@qmul.ac.uk.ORCID http://orcid.org/0000-0002-4176-2947
Joanna M M HowsonBritish Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. JMMHowson@gmail.com.ORCID http://orcid.org/0000-0001-7618-0050
University of Cambridge · GBQueen Mary University of London · GBBrigham and Women's Hospital · USUniversity Medical Center Groningen · NLLund University · SEdeCODE Genetics (Iceland) · ISCentre for Human Genetics · GBUniversity of Michigan · USUniversity of Copenhagen · DKBroad Institute · USUppsala University · SEBoston University · USFinnish Institute for Health and Welfare · FILeiden University Medical Center · NLNational Institutes of Health · USUniversitätsmedizin Greifswald · DEUniversity of Bristol · GBUniversity of Eastern Finland · FIUniversity of Helsinki · FIUniversity of Leicester · GB

Funding

The Genetic Determinants of Human GNRH DeficiencyP50HD028138 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI SEMINARA, STEPHANIE BETH · 2014 to 2020
$12.9M
Identifying Genes for Type 2 Diabetes: FUSIONU01DK062370 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BOEHNKE, MICHAEL L, SCOTT, LAURA J. · 2009 to 2021
$11.6M
Targeted Genetic Analysis of T2D and Quantitative TraitsR01DK072193 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KAREN L. MOHLKE · 2005 to 2026
$11.3M
Building Interdisciplinary Research Careers in Women's HealthK12HD043483 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HARTMANN, KATHERINE E, MAJOR, AMY S · 2002 to 2023
$10.3M
CHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5M
Rare variants and NHLBI traits in deeply phenotyped cohortsR01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2014 to 2016
$8.9M
Genetic epidemiology of rare and regulatory variants for metabolic traitsR01DK093757 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KAREN L. MOHLKE · 2011 to 2026
$8.2M
Identifying Genes for Type 2 Diabetes:FUSIONR01DK062370 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BOEHNKE, MICHAEL L, SCOTT, LAURA J. · 2003 to 2025
$6.7M
Rare variants and NHLBI traits in deeply phenotyped cohortsU01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2017 to 2018
$5.6M
Vanderbilt Training Program in Molecular and Genetic Epidemiology of CancerT32CA160056 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Xiao-Ou Shu · 2017 to 2026
$3.8M
Leveraging ancestry to map kidney lociR01MD012765 · NIMHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FRANCESCHINI, NORA · 2017 to 2021
$3.6M
Diverse ancestry biobank to map biomedical traits and elucidate health disparitieU01HG007417 · NHGRI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI LOOS, RUTH JF · 2013 to 2017
$3.5M
British Heart Foundation PG/17/35/33001British Heart Foundation PG/19/16/34270British Heart Foundation RE/18/6/34217British Heart Foundation RG/13/13/30194British Heart Foundation RG/14/5/30893British Heart Foundation RG/18/13/33946British Heart Foundation SP/09/002Cancer Research UK 14136Department of Health NF-SI-0617-10090European Research Council 268834Medical Research Council G0401527Medical Research Council G0800270Medical Research Council G1000143Medical Research Council G9521010Medical Research Council MC_PC_MR/R020183/1Medical Research Council MC_PC_U127592696Medical Research Council MC_U106179471Medical Research Council MC_UU_00002/7Medical Research Council MC_UU_00006/1Medical Research Council MC_UU_00007/10Medical Research Council MC_UU_00011/1Medical Research Council MC_UU_00011/4Medical Research Council MC_UU_00011/5Medical Research Council MC_UU_00026/3Medical Research Council MC_UU_12013/2Medical Research Council MC_UU_12015/1Medical Research Council MR/L003120/1Medical Research Council MR/L01341X/1Medical Research Council MR/N003284/1Medical Research Council MR/R023484/1Medical Research Council MR/S003746/1Medical Research Council MR/S004068/1Medical Research Council MR/S004068/2NCI NIH HHS T32 CA160056NHGRI NIH HHS U01 HG007417NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL120393NHLBI NIH HHS R21 HL123677NHLBI NIH HHS R21 HL140385NHLBI NIH HHS U01 HL120393NICHD NIH HHS K12 HD043483NICHD NIH HHS P50 HD028138NIDDK NIH HHS R01 DK062370NIDDK NIH HHS R01 DK072193NIDDK NIH HHS R01 DK093757NIDDK NIH HHS R01 DK101855NIDDK NIH HHS R01 DK107786NIDDK NIH HHS R01 DK110113NIDDK NIH HHS R01 DK117445NIDDK NIH HHS U01 DK062370NIMHD NIH HHS R01 MD012765Wellcome Trust 090532Wellcome Trust 098381Wellcome Trust 106130Wellcome Trust 202802/Z/16/ZWellcome Trust 203141Wellcome Trust 204623/Z/16/ZWellcome Trust 212259Wellcome Trust 212945/Z/18/Z
6 · The paper itself

Abstract

Genetic studies of blood pressure (BP) to date have mainly analyzed common variants (minor allele frequency > 0.05). In a meta-analysis of up to ~1.3 million participants, we discovered 106 new BP-associated genomic regions and 87 rare (minor allele frequency ≤ 0.01) variant BP associations (P < 5 × 10

Indexed as

Blood PressureGATA5 Transcription FactorGene FrequencyGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeHumansHypertensionMutationPhospholipase C betaPolymorphism, Single NucleotideGATA5 protein, humanGATA5 Transcription FactorPhospholipase C betaPLCB3 protein, human

Identifiers

PMID33230300
PMCPMC7610439
OpenAlexW3109183357

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