Evidence map›Paper›PMID 33230240›Full record

ArticleScientific reports2020

Gestational age is related to symptoms of attention-deficit/hyperactivity disorder in late-preterm to full-term children and adolescents with down syndrome.

Laura Del Hoyo Soriano, Tracie Rosser, Debra Hamilton, Taylor Wood, Leonard Abbeduto, Stephanie Sherman

Open access · goldAbstract readMulticenter Study
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
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  4. Article
  5. Review
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  7. Article
  8. Cognitive outcome measures for tracking Alzheimer's disease in Down syndrome.International review of research in developmental disabilities · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Laura Del Hoyo SorianoDepartment of Psychiatry and Behavioral Sciences, MIND Institute University of California Davis, Sacramento, CA, USA. ldelhoyo@ucdavis.edu.
Tracie RosserDepartment of Human Genetics, Emory University School of Medicine, Atlanta, GA, USA.
Debra HamiltonDepartment of Human Genetics, Emory University School of Medicine, Atlanta, GA, USA.
Taylor WoodDepartment of Psychiatry and Behavioral Sciences, MIND Institute University of California Davis, Sacramento, CA, USA.
Leonard AbbedutoDepartment of Psychiatry and Behavioral Sciences, MIND Institute University of California Davis, Sacramento, CA, USA.
Stephanie ShermanDepartment of Human Genetics, Emory University School of Medicine, Atlanta, GA, USA.
Emory University · USUniversity of California, Davis · US

Funding

WISCONSIN CENTER ON MENTAL RETARDATION: CORE SUPPORTP30HD003352 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI DAVIDSON, RICHARD J · 1985 to 2015
$25.2M
Research Project: Pathologic Significance of Maternal AutoantibodiesP50HD103526 · NICHD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI LEONARD J. ABBEDUTO, Melissa Dawn Bauman · 2020 to 2026
$9.7M
Rodent Behavior CoreU54HD079125 · NICHD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI ABBEDUTO, LEONARD J. · 2013 to 2019
$8.5M
Waisman Intellectual and Developmental Disabilities Research Center Down Syndrome RegistryU54HD090256 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI CHANG, QIANG · 2016 to 2020
$6.0M
NICHD NIH HHS P30 HD003352NICHD NIH HHS P50 HD103526NICHD NIH HHS U54 HD079125NICHD NIH HHS U54 HD090256NIH HHS P30HD03352NIH HHS U54HD079125NIH HHS U54HD090256
6 · The paper itself

Abstract

Attention-deficit/hyperactivity disorder is frequently reported in individuals with Down syndrome, with considerable variation in the expression and severity of the symptoms. Despite growing evidence that gestational age predicts later symptoms of attention-deficit/hyperactivity disorder in the euploid population, this has not been studied in down syndrome. The current study is designed to investigate the influence of gestational age in later symptoms of attention-deficit/hyperactivity disorder in 105 individuals (49 males and 56 females; aged 6-18 years) with Down syndrome who were born at or after 35 weeks gestation. Maternal age at birth, maternal level of education, household income, as well as sex, chronological age, and cognitive level of the participant with Down syndrome were considered in our analysis. Results from this study show that gestational age is related to inattentive and hyperactive/impulsive symptoms in children and adolescents with Down syndrome. Therefore, gestational age should be addressed when considering symptoms of attention-deficit/hyperactivity disorder, as it may have implications for early interventions. More attention is needed toward the advancement of care and follow-up for infants with down syndrome who are born even late preterm or early term.

Indexed as

Gestational AgeAdolescentAttention Deficit Disorder with HyperactivityChildCognitionComorbidityDown SyndromeEducational StatusFemaleHumansIncomeMaleMaternal AgePregnancyPremature BirthRetrospective Studies

Identifiers

PMID33230240
PMCPMC7683733
OpenAlexW3109129620

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.