ArticleScientific reports2020
On-line range verification for proton beam therapy using spherical ionoacoustic waves with resonant frequency.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Bridging Photoacoustic and Protoacoustic Imaging: Material Heterogeneity Effects on Proton Range Verification Using Time-of-Flight Analysis.Bioengineering (Basel, Switzerland) · 2025Article
- Proton Range Measurement Precision in Ionoacoustic Experiments with Wavelet-Based Denoising Algorithm.Sensors (Basel, Switzerland) · 2025Article
- Toward real-time, volumetric dosimetry for FLASH-capable clinical synchrocyclotrons using protoacoustic imaging.Medical physics · 2024Article
- Real-time tracking of the Bragg peak during proton therapy via 3D protoacoustic Imaging in a clinical scenario.Npj imaging · 2024Article
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In contrast to conventional X-ray therapy, proton beam therapy (PBT) can confine radiation doses to tumours because of the presence of the Bragg peak. However, the precision of the treatment is currently limited by the uncertainty in the beam range. Recently, a unique range verification methodology has been proposed based on simulation studies that exploit spherical ionoacoustic waves with resonant frequency (SPIREs). SPIREs are emitted from spherical gold markers in tumours initially introduced for accurate patient positioning when the proton beam is injected. These waves have a remarkable property: their amplitude is linearly correlated with the residual beam range at the marker position. Here, we present proof-of-principle experiments using short-pulsed proton beams at the clinical dose to demonstrate the feasibility of using SPIREs for beam-range verification with submillimetre accuracy. These results should substantially contribute to reducing the range uncertainty in future PBT applications.
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