ArticleNature communications2020
Common and distinct neural representations of aversive somatic and visceral stimulation in healthy individuals.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07209566 (The Effect of Vaginal Somatovisceral Pain on Hip Extension Mobility and Strength in Women at Mid-cycle With Dysmenorrhea vs. Controls), which is not on this map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Vaginal Somatovisceral Pain on Hip Extension Mobility and Strength in Women at Mid-cycle With Dysmenorrhea vs. Controls: A Case-control Study
Who cites it
30 citing papers in PubMed.
- Trial
- Emotional brain responses and pattern expressions in right temporal variant frontotemporal dementia.Journal of neurology · 2026Article
- Mapping Pain Memory Across Modalities: Distinct Spatial Representations of Recalled Visceral and Somatic Pain.European journal of pain (London, England) · 2026Article
- Latent neural architecture organising shared aesthetic evaluations of visual artworks.Nature communications · 2026Article
- Inside-Out Mechanism of Referred Visceral Pain: Protocol for a Systematic Review of Cutaneous Neurogenic Inflammation in Preclinical Animal Models of Visceral Diseases.JMIR research protocols · 2026Article
- Convergent and selective representations of pain, appetitive processes, aversive processes, and cognitive control in the insula.Nature communications · 2026Article
- Effect of Stretching on the Electroencephalography of People With Irritable Bowel Syndrome.Cureus · 2025Article
- Action-mode subnetworks for decision-making, action control, and feedback.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- A sensation driven functional MRI study on brain activation during bladder filling in healthy participants.Scientific reports · 2025Article
- Risk Factors for Chronic Pain in Women: The Role of Violence Exposure in a Case-Control Study.Life (Basel, Switzerland) · 2025Article
- The brain's action-mode network.Nature reviews. Neuroscience · 2025Review
- Visceral Pain in Preterm Infants with Necrotizing Enterocolitis: Underlying Mechanisms and Implications for Treatment.Paediatric drugs · 2025Review
- Protocol for prognosticating PPD using EEG changes during labor pain by uterine contractions: a prospective cohort study in the first stage of labor.BMC pregnancy and childbirth · 2025Article
- Pipeline variability: Friend or foe, depending on the goal: Comment on Germani et al. 2025.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Functional movement disorder is associated with abnormal interoceptive brain activity: a task-based functional MRI study.Frontiers in psychiatry · 2025Article
- The expectations humans have of a pleasurable sensation asymmetrically shape neuronal responses and subjective experiences to hot sauce.PLoS biology · 2024Article
- Functional Movement Disorder Is Associated with Abnormal Interoceptive Brain Activity: A Task-based Functional MRI Study.medRxiv : the preprint server for health sciences · 2024Article
- Systematic reduction of gray matter volume in anorexia nervosa, but relative enlargement with clinical symptoms in the prefrontal and posterior insular cortices: a multicenter neuroimaging study.Molecular psychiatry · 2024Article
- Distinct Alterations in Central Pain Processing of Visceral and Somatic Pain in Quiescent Ulcerative Colitis Compared to Irritable Bowel Syndrome and Health.Journal of Crohn's & colitis · 2023Article
- Parieto-occipital ERP indicators of gut mechanosensation in humans.Nature communications · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
Abstract
Different pain types may be encoded in different brain circuits. Here, we examine similarities and differences in brain processing of visceral and somatic pain. We analyze data from seven fMRI studies (N = 165) and five types of pain and discomfort (esophageal, gastric, and rectal distension, cutaneous thermal stimulation, and vulvar pressure) to establish and validate generalizable pain representations. We first evaluate an established multivariate brain measure, the Neurologic Pain Signature (NPS), as a common nociceptive pain system across pain types. Then, we develop a multivariate classifier to distinguish visceral from somatic pain. The NPS responds robustly in 98% of participants across pain types, correlates with perceived intensity of visceral pain and discomfort, and shows specificity to pain when compared with cognitive and affective conditions from twelve additional studies (N = 180). Pre-defined signatures for non-pain negative affect do not respond to visceral pain. The visceral versus the somatic classifier reliably distinguishes somatic (thermal) from visceral (rectal) stimulation in both cross-validation and independent cohorts. Other pain types reflect mixtures of somatic and visceral patterns. These results validate the NPS as measuring a common core nociceptive pain system across pain types, and provide a new classifier for visceral versus somatic pain.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.