ArticleScientific reports2020
Analysis of the three dimensional structure of the kidney glomerulus capillary network.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 35 citations in OpenAlex.
- Development of a customizable vascularization strategy using a modular microfluidic platform for fibroblast-free vascularized tissue.Materials today. Bio · 2026Article
- Super-resolved optical imaging, reconstruction, and spatial analysis of whole mouse glomeruli via the Glomerulus Mapping and Analysis Pipeline.Kidney international · 2025Article
- Production of Irregularly Shaped True-To-Life Microplastics with Embedded Optical Labels and Exemplary Application in an Ex Vivo Model.Environmental science & technology · 2025Article
- Polymorphisms in SAA alter intrarenal amyloid distribution of AA amyloidosis in cats.Scientific reports · 2025Article
- Label-free multimodal optical biopsy reveals biomolecular and morphological features of diabetic kidney tissue in 2D and 3D.Nature communications · 2025Article
- Hemodynamic simulation andPhysics of fluids (Woodbury, N.Y. : 1994) · 2025Article
- Automated Euler number of the alveolar capillary network based on deep learning segmentation with verification by stereological methods.Journal of microscopy · 2025Article
- Article
- Label-Free Optical Biopsy Reveals Biomolecular and Morphological Features of Diabetic Kidney Tissue in 2D and 3D.bioRxiv : the preprint server for biology · 2024Article
- During Postnatal Ontogenesis, the Development of a Microvascular Bed in an Intestinal Villus Depends on Intussusceptive Angiogenesis.International journal of molecular sciences · 2024Article
- New Interpretations for Sprouting, Intussusception, Ansiform, and Coalescent Types of Angiogenesis.International journal of molecular sciences · 2024Review
- Array tomography: trails to discovery.Methods in microscopy · 2024Article
- Glomerular microcirculation: Implications for diabetes, preeclampsia, and kidney injury.Acta physiologica (Oxford, England) · 2023Review
- High-resolution alignment of single-cell and spatial transcriptomes with CytoSPACE.Nature biotechnology · 2023Article
- Poroelastic modelling reveals the cooperation between two mechanisms for albuminuria.Journal of the Royal Society, Interface · 2023Article
- Compact laboratory-based X-ray microscope enabling nondestructive 3D structure acquisition of mouse nephron with high speed and better user accessibility.Microscopy (Oxford, England) · 2022Article
- Computational Identification and 3D Morphological Characterization of Renal Glomeruli in Optically Cleared Murine Kidneys.Sensors (Basel, Switzerland) · 2021Article
- Map3D: Registration-Based Multi-Object Tracking on 3D Serial Whole Slide Images.IEEE transactions on medical imaging · 2021Article
- AI applications in renal pathology.Kidney international · 2021Review
- Niwaki Instead of Random Forests: Targeted Serial Sectioning Scanning Electron Microscopy With Reimaging Capabilities for Exploring Central Nervous System Cell Biology and Pathology.Frontiers in neuroanatomy · 2021Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The capillary network of the kidney glomerulus filters small molecules from the blood. The glomerular 3D structure should help to understand its function, but it is poorly characterized. We therefore devised a new approach in which an automated tape collecting microtome (ATUM) was used to collect 0.5 μm thick serial sections from fixed mouse kidneys. The sections were imaged by scanning electron microscopy at ~ 50 nm/pixel resolution. With this approach, 12 glomeruli were reconstructed at an x-y-z resolution ~ 10 × higher than that of paraffin sections. We found a previously undescribed no-cross zone between afferent and efferent branches on the vascular pole side; connections here would allow blood to exit without being adequately filtered. The capillary diameters throughout the glomerulus appeared to correspond with the amount of blood flow within them. The shortest path (minimum number of branches to travel from afferent to efferent arterioles) is relatively independent of glomerular size and is present primarily on the vascular pole size. This suggests that new branches and longer paths form on the urinary pole side. Network analysis indicates that the glomerular network does not form by repetitive longitudinal splitting of capillaries. Thus the 3D structure of the glomerular capillary network provides useful information with which to understand glomerular function. Other tissue structures in the body may benefit from this new three dimensional approach.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.