Evidence map›Paper›PMID 33230115›Full record

ArticleScientific reports2020

A novel Schmallenberg virus subunit vaccine candidate protects IFNAR

Hani Boshra, Gema Lorenzo, Diego Charro, Sandra Moreno, Gabriel Soares Guerra, Isbene Sanchez, Joseba M Garrido, Marivi Geijo, Alejandro Brun, Nicola G A Abrescia

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.4field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Hani BoshraCenter for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, 48160, Derio, Spain. hboshra@uliege.be.
Gema LorenzoAnimal Health Research Center (INIA-CISA), 28130, Valdeolmos, Madrid, Spain.
Diego CharroCenter for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, 48160, Derio, Spain.
Sandra MorenoAnimal Health Research Center (INIA-CISA), 28130, Valdeolmos, Madrid, Spain.
Gabriel Soares GuerraCenter for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, 48160, Derio, Spain.
Isbene SanchezVacunek SL, Bizkaia Technology Park, 48160, Derio, Spain.
Joseba M GarridoAnimal Health Department, NEIKER-Basque Institute for Agricultural Research and Development, Derio, Bizkaia, Spain.
Marivi GeijoAnimal Health Department, NEIKER-Basque Institute for Agricultural Research and Development, Derio, Bizkaia, Spain.
Alejandro BrunAnimal Health Research Center (INIA-CISA), 28130, Valdeolmos, Madrid, Spain.
Nicola G A AbresciaCenter for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, 48160, Derio, Spain. nabrescia@cicbiogune.es.
CIC bioGUNE · ESNEIKER, the Basque Institute for Agricultural Research and Development · ESEuskadiko Parke Teknologikoa · ESIkerbasque · ES

Funding

Marie Curie MSCAIF- EF-ST-660155
6 · The paper itself

Abstract

Schmallenberg virus (SBV), an arthropod-transmitted pathogenic bunyavirus, continues to be a threat to the European livestock industry, causing morbidity and mortality among young ruminant livestock. Here, we describe a novel SBV subunit vaccine, based on bacterially expressed SBV nucleoprotein (SBV-N) administered with a veterinary-grade Saponin adjuvant. When assayed in an IFNAR

Indexed as

Adjuvants, ImmunologicAnimalsAntibodies, ViralAntibody SpecificityBroadly Neutralizing AntibodiesBunyaviridae InfectionsInterferon-gammaIn Vitro TechniquesLymphocyte ActivationMiceMice, KnockoutOrthobunyavirusReceptor, Interferon alpha-betaRuminantsSaponinsVaccines, SubunitAdjuvants, ImmunologicAntibodies, ViralBroadly Neutralizing AntibodiesIfnar1 protein, mouseInterferon-gammaReceptor, Interferon alpha-betaSaponinsVaccines, SubunitViral Vaccines

Identifiers

PMID33230115
PMCPMC7684302
OpenAlexW3107951352

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.