Evidence map›Paper›PMID 33229855›Full record

ArticleJournal of atherosclerosis and thrombosis2021

Improvement in Brachial Endothelial Vasomotor Function and Brachial-Ankle Pulse Wave Velocity Reduces the Residual Risk for Cardiovascular Events after Optimal Medical Treatment in Patients with Coronary Artery Disease.

Takamitsu Nakamura, Manabu Uematsu, Takeo Horikoshi, Toru Yoshizaki, Tsuyoshi Kobayashi, Yukio Saito, Yosuke Watanabe, Kazuto Nakamura, Jun-Ei Obata, Kiyotaka Kugiyama

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of atherosclerosis and thrombosis, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

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  4. Usefulness of Arterial Stiffness as an Integrated Marker of Cardiovascular Risk.Journal of clinical hypertension (Greenwich, Conn.) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Takamitsu NakamuraDepartment of Internal Medicine II, University of Yamanashi, Faculty of Medicine.
Manabu UematsuDepartment of Internal Medicine II, University of Yamanashi, Faculty of Medicine.
Takeo HorikoshiDepartment of Internal Medicine II, University of Yamanashi, Faculty of Medicine.
Toru YoshizakiDepartment of Internal Medicine II, University of Yamanashi, Faculty of Medicine.
Tsuyoshi KobayashiDepartment of Internal Medicine II, University of Yamanashi, Faculty of Medicine.
Yukio SaitoDepartment of Internal Medicine II, University of Yamanashi, Faculty of Medicine.
Yosuke WatanabeDepartment of Internal Medicine II, University of Yamanashi, Faculty of Medicine.
Kazuto NakamuraDepartment of Internal Medicine II, University of Yamanashi, Faculty of Medicine.
Jun-Ei ObataDepartment of Internal Medicine II, University of Yamanashi, Faculty of Medicine.
Kiyotaka KugiyamaDepartment of Internal Medicine II, University of Yamanashi, Faculty of Medicine.
University of Yamanashi · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo examine whether improvement in flow-mediated endothelium-dependent dilatation (FMD) of the brachial artery and brachial-ankle pulse wave velocity (baPWV) has an additive effect on achieving optimal goals of traditional risk factors to reduce cardiovascular risk in patients with coronary artery disease (CAD).

methodsWe assessed 323 patients with CAD and impaired vascular function, defined as an impaired FMD of the brachial artery (＜5.5%) and increased baPWV (＞1,440 cm/sec). After FMD and baPWV measurements at 24 weeks of optimal medical treatment (OMT), the study patients were followed up for ＜60 months or until a composite of cardiac death, nonfatal myocardial infarction (MI), unstable angina, or ischemic stroke occurs.

resultsDuring the median follow-up period of 35 months, cardiovascular events occurred in 72 patients. Multivariate Cox hazards analysis showed that patients with an improvement in FMD and baPWV had the lowest probability of future cardiovascular events. In addition, the improvement in FMD and baPWV had a significant incremental effect on the predictive value of the achievement of optimal goals for blood pressure (BP), low-density lipoprotein cholesterol (LDL-C), and hemoglobin A1c (HbA1c) using net reclassification improvement (NRI) and integrated discrimination improvement (IDI).

conclusionsThe improvement in FMD and baPWV had additive effects on risk reduction of the achievement of the optimal goals of traditional risk factors in patients with CAD. Thus, serial measurements of FMD and baPWV may be useful for identifying CAD patients at residual risk for adverse cardiovascular events following OMT.

Indexed as

Ankle Brachial IndexAgedBlood Flow VelocityBrachial ArteryCoronary Artery DiseaseEndothelium, VascularFemaleFollow-Up StudiesHeart Disease Risk FactorsHumansJapanMalePrognosisProspective StudiesPulse Wave AnalysisSurvival RateArterial stiffnessEndothelial functionFlow-mediated dilationPulse wave velocityResidual risk

Identifiers

PMID33229855
PMCPMC8592703
OpenAlexW3109015426

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.