Evidence map›Paper›PMID 33229808›Full record

ArticleInternal medicine (Tokyo, Japan)2021

The Effect of Intravenous Methylprednisolone on Recurrent Exacerbation in Hematologic Malignancy-associated Progressive Multifocal Leukoencephalopathy.

Ryutaro Nakamura, Akihiro Kitamura, Takahito Tsukamoto, Ryota Tamura, Nobuhiro Ogawa, Isamu Yamakawa, Hyoh Kim, Michihiro Kawai, Mitsuru Sanada, Makoto Urushitani

Open access · diamondAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Ryutaro NakamuraDepartment of Neurology, Shiga University of Medical Science, Japan.
Akihiro KitamuraDepartment of Neurology, Shiga University of Medical Science, Japan.
Takahito TsukamotoDepartment of Neurology, Shiga University of Medical Science, Japan.
Ryota TamuraDepartment of Neurology, Shiga University of Medical Science, Japan.
Nobuhiro OgawaDepartment of Neurology, Shiga University of Medical Science, Japan.
Isamu YamakawaDepartment of Neurology, Shiga University of Medical Science, Japan.
Hyoh KimDepartment of Neurology, Shiga University of Medical Science, Japan.
Michihiro KawaiDepartment of Neurology, Shiga University of Medical Science, Japan.
Mitsuru SanadaDepartment of Neurology, Shiga University of Medical Science, Japan.
Makoto UrushitaniDepartment of Neurology, Shiga University of Medical Science, Japan.
Shiga University of Medical Science · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We herein report a 65-year-old man with progressive multifocal leukoencephalopathy (PML) after 2-year remission from acute myeloid leukemia who developed recurrent episodes of left hemiparesis with gadolinium enhancement on magnetic resonance imaging. Steroid pulse therapy for each exacerbation induced clinical and radiological improvement, suggesting that exacerbations are an excessive immune response to the JC virus and distinct from immune reconstitution inflammatory syndrome (IRIS). Although glucocorticoids are recommended only for IRIS, steroid pulse therapy should be considered as a therapeutic option in cases of exacerbation of hematologic malignancy-associated PML. Importantly, neuroimaging is not sufficient to differentiate excessive inflammation from a controlled inflammatory response, for which steroids are not recommended.

Indexed as

Hematologic NeoplasmsImmune Reconstitution Inflammatory SyndromeJC VirusLeukoencephalopathy, Progressive MultifocalAgedContrast MediaGadoliniumHumansMagnetic Resonance ImagingMaleMethylprednisoloneContrast MediaGadoliniumMethylprednisolonehematologic malignancy-associated PMLinflammatory PMLIRISPMLPML with controlled inflammatory response

Identifiers

PMID33229808
PMCPMC8112991
OpenAlexW3108993784

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.