Evidence map›Paper›PMID 33229725›Full record

ArticleNeural regeneration research2021

Therapeutic potential of dental pulp stem cell transplantation in a rat model of Alzheimer's disease.

Xue-Mei Zhang, Yuan-Jiao Ouyang, Bing-Qian Yu, Wei Li, Mei-Yu Yu, Jin-Yue Li, Zhuo-Min Jiao, Dan Yang, Na Li, Ying Shi and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neural regeneration research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 35 citations in OpenAlex.

  1. Review
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  4. Human dental pulp stem cells for spinal cord injury.Stem cell research & therapy · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 1 institution in 1 country.

Xue-Mei ZhangDepartment of Neurology, The 2nd Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China.
Yuan-Jiao OuyangDepartment of Neurology, The 2nd Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China.
Bing-Qian YuDepartment of Neurology, Ningbo Hangzhou Bay Hospital, Ningbo, Zhejiang Province, China.
Wei LiDepartment of Neurology, The 2nd Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China.
Mei-Yu YuDepartment of Neurology, The 2nd Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China.
Jin-Yue LiDepartment of Neurology, The 2nd Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China.
Zhuo-Min JiaoDepartment of Neurology, The 2nd Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China.
Dan YangDepartment of Neurology, The 2nd Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China.
Na LiDepartment of Neurology, the First Hospital of Qiqihar, Qiqihar, Heilongjiang Province, China.
Ying ShiDepartment of Neurology, The 2nd Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China.
Yun-Yun XuDepartment of Neurology, The 2nd Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China.
Zhi-Jun HeDepartment of Neurology, The 2nd Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China.
Duo WangDepartment of Neurology, The 2nd Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China.
Hui YueDepartment of Neurology, The 2nd Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China.
Jin FuDepartment of Neurology, The 2nd Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China.
Qiqihar Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dental pulp stem cells are dental pulp-derived mesenchymal stem cells that originate from the neural crest. They exhibit greater potential for the treatment of nervous system diseases than other types of stem cells because of their neurogenic differentiation capability and their ability to secrete multiple neurotrophic factors. Few studies have reported Alzheimer's disease treatment using dental pulp stem cells. Rat models of Alzheimer's disease were established by injecting amyloid-β1-42 into the hippocampus. Fourteen days later, 5 × 10

Indexed as

Alzheimer’s diseasebraincentral nervous systemdental pulp stem cellin vivomodelratstem cellstransplantation

Identifiers

PMID33229725
PMCPMC8178760
OpenAlexW3102359864

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.