ArticleProceedings of the National Academy of Sciences of the United States of America2020
ATP13A2-mediated endo-lysosomal polyamine export counters mitochondrial oxidative stress.
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In one paragraph
Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed, 1 pooled it
7.7field-weighted citation impact, top 2% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
64 citing papers in PubMed, 1 synthesis or guideline pooled it, 102 citations in OpenAlex.
- Inter-organellar Communication in Parkinson's and Alzheimer's Disease: Looking Beyond Endoplasmic Reticulum-Mitochondria Contact Sites.Frontiers in neuroscience · 2022Pooled it
- Functional Characterization of the P-Type ATPases ATP13A3 and ATP13A4 as Plasma Membrane Polyamine Transporters.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Spermidine in Colorectal cancer: friend or foe?Amino acids · 2026Review
- Polyamine metabolism in ischemia reperfusion injury: common mitochondrial mechanisms and organ-specific differences.Journal of translational medicine · 2026Review
- Evaluation of an Integrated In Silico-In Vitro Pipeline for Predicting Mitochondrial Complex I-Mediated Neurotoxicity of Chlorpyrifos.Neurotoxicity research · 2026Article
- Identification of divergent organ-specific gene and protein expression signatures for mitochondrial function, inflammatory response, and proteostasis in the liver and brain in the rotenone-induced rat model of Parkinson's disease.Molecular biology reports · 2026Article
- Serum L-ornithine-derived polyamines as indicators of Parkinson disease progression.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- Spermidine in the aging brain: mechanisms, preclinical evidence, and clinical perspectives.Molecular biology reports · 2026Review
- Progress in modelling ATP13A2-linked neurodegeneration.NPJ Parkinson's disease · 2026Review
- ATP13A2 restrains macrophage NLRP3 inflammasome activation to repress neurodegeneration via modulating mitochondrial homeostasis.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Two lysosomal genes ATP13A2 and GBA1 interact to drive neurodegeneration.Molecular neurodegeneration · 2026Article
- Depleted before the dose: the mitochondrial vulnerability threshold hypothesis for fluoroquinolone-associated multisystem toxicity.Frontiers in pharmacology · 2026Article
- Polyamine Metabolism in Brain Health and Disease.Neuropharmacology and therapy · 2026Article
- The functional roles and mechanisms of polyamines in age-related bone diseases.Cellular and molecular life sciences : CMLS · 2025Review
- A noncanonical polyamine from bacteria antagonizes host mitochondrial function.Nature communications · 2025Article
- Trans-omics analyses identify the biochemical network of LPCAT1 associated with coronary artery disease.Biomarker research · 2025Article
- HB52-PUT2 Module-Mediated Polyamine Shoot-to-Root Movement Regulates Salt Stress Tolerance in Tomato.Plant, cell & environment · 2025Article
- Oxidative Stress: Pathological Driver in Chronic Neurodegenerative Diseases.Antioxidants (Basel, Switzerland) · 2025Review
- Mitochondrial Dysfunction in Genetic and Non-Genetic Parkinson's Disease.International journal of molecular sciences · 2025Review
- Rescue of a Rotenone Model of Parkinson's Disease inInternational journal of molecular sciences · 2025Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 7 institutions in 4 countries.
Stephanie VrijsenLaboratory of Cellular Transport Systems, Department of Cellular and Molecular Medicine, Katholieke Universiteit Leuven (KU Leuven), 3000 Leuven, Belgium.ORCID 0000-0002-2601-510X
Laura Besora-CasalsCell and Developmental Biology, Department Biology II, Ludwig Maximilians Universität, 80539 Münich, Germany.ORCID 0000-0001-5113-957X
Sarah van VeenLaboratory of Cellular Transport Systems, Department of Cellular and Molecular Medicine, Katholieke Universiteit Leuven (KU Leuven), 3000 Leuven, Belgium.ORCID 0000-0002-7639-7847
Jeffrey ZielichCell and Developmental Biology, Department Biology II, Ludwig Maximilians Universität, 80539 Münich, Germany.ORCID 0000-0003-4879-0649
Chris Van den HauteLaboratory for Neurobiology and Gene Therapy, Department of Neurosciences, KU Leuven, 3000 Leuven, Belgium.
Norin Nabil HamoudaLaboratory of Cellular Transport Systems, Department of Cellular and Molecular Medicine, Katholieke Universiteit Leuven (KU Leuven), 3000 Leuven, Belgium.
Christian FischerCell and Developmental Biology, Department Biology II, Ludwig Maximilians Universität, 80539 Münich, Germany.
Bart GhesquièreMetabolomics Expertise Center, Vlaams Instituut voor Biotechnologie (VIB)-KU Leuven Center for Cancer Biology, Department of Oncology, KU Leuven, 3000 Leuven, Belgium.ORCID 0000-0003-1547-1705
Ivailo TournevDepartment of Neurology, Medical University-Sofia, 1431 Sofia, Bulgaria.
Patrizia AgostinisLaboratory of Cell Death Research and Therapy, VIB-KU Leuven Center for Cancer Biology, Department of Cellular and Molecular Medicine, KU Leuven, 3000 Leuven, Belgium.
Veerle BaekelandtLaboratory for Neurobiology and Gene Therapy, Department of Neurosciences, KU Leuven, 3000 Leuven, Belgium.
Jan EggermontLaboratory of Cellular Transport Systems, Department of Cellular and Molecular Medicine, Katholieke Universiteit Leuven (KU Leuven), 3000 Leuven, Belgium.ORCID 0000-0002-8497-1159
Eric LambieCell and Developmental Biology, Department Biology II, Ludwig Maximilians Universität, 80539 Münich, Germany.ORCID 0000-0002-7371-128X
Shaun MartinLaboratory of Cellular Transport Systems, Department of Cellular and Molecular Medicine, Katholieke Universiteit Leuven (KU Leuven), 3000 Leuven, Belgium.
Peter VangheluweLaboratory of Cellular Transport Systems, Department of Cellular and Molecular Medicine, Katholieke Universiteit Leuven (KU Leuven), 3000 Leuven, Belgium; peter.vangheluwe@kuleuven.be.ORCID 0000-0002-7822-2944
KU Leuven · BELudwig-Maximilians-Universität München · DECenter for Integrated Protein Science Munich · DEMedical University of Sofia · BGUniversity College London · GBVIB-KU Leuven Center for Cancer Biology · BEVlaams Instituut voor Biotechnologie · BE
Funding
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5MNIH HHS P40 OD010440
Abstract
Recessive loss-of-function mutations in
Indexed as
Activating Transcription Factor 4Adenosine TriphosphatasesAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsEflornithineFibroblastsLysosomesMitochondriaMutationOxidative StressParkinson DiseasePolyaminesProton-Translocating ATPasesRotenoneSpermineActivating Transcription Factor 4Adenosine TriphosphatasesATF4 protein, humanATFS-1 protein, C elegansATP13A2 protein, humanCaenorhabditis elegans ProteinsCATP-6 protein, C elegansDDIT3 protein, humanEflornithinePolyaminesProton-Translocating ATPasesRotenoneSpermineTranscription Factor CHOPTranscription FactorsantioxidantmitochondrianeurodegenerationP5B-type ATPasepolyamine transport
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.