Evidence map›Paper›PMID 33229531›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

Studies in bank voles reveal strain differences between chronic wasting disease prions from Norway and North America.

Romolo Nonno, Michele A Di Bari, Laura Pirisinu, Claudia D'Agostino, Ilaria Vanni, Barbara Chiappini, Stefano Marcon, Geraldina Riccardi, Linh Tran, Turid Vikøren and 6 more

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 128 citations in OpenAlex.

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  4. Regulated coexpression of PrP from different species in mice impacts the replication and host range properties of prion strains.Proceedings of the National Academy of Sciences of the United States of America · 2025
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3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 4 countries.

Romolo NonnoDepartment of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanità, 00161 Rome, Italy; romolo.nonno@iss.it.ORCID 0000-0001-7556-1564
Michele A Di BariDepartment of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanità, 00161 Rome, Italy.ORCID 0000-0003-0943-6823
Laura PirisinuDepartment of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanità, 00161 Rome, Italy.
Claudia D'AgostinoDepartment of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanità, 00161 Rome, Italy.
Ilaria VanniDepartment of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanità, 00161 Rome, Italy.ORCID 0000-0003-2617-4263
Barbara ChiappiniDepartment of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanità, 00161 Rome, Italy.ORCID 0000-0002-5260-5285
Stefano MarconDepartment of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanità, 00161 Rome, Italy.
Geraldina RiccardiDepartment of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanità, 00161 Rome, Italy.
Linh TranWorld Organization for Animal Health Reference Laboratory for Chronic Wasting Disease, Norwegian Veterinary Institute, N-0106 Oslo, Norway.
Turid VikørenWorld Organization for Animal Health Reference Laboratory for Chronic Wasting Disease, Norwegian Veterinary Institute, N-0106 Oslo, Norway.
Jørn VågeWorld Organization for Animal Health Reference Laboratory for Chronic Wasting Disease, Norwegian Veterinary Institute, N-0106 Oslo, Norway.ORCID 0000-0002-2016-0111
Knut MadslienWorld Organization for Animal Health Reference Laboratory for Chronic Wasting Disease, Norwegian Veterinary Institute, N-0106 Oslo, Norway.
Gordon MitchellNational and World Organization for Animal Health Reference Laboratory for Scrapie and Chronic Wasting Disease, Canadian Food Inspection Agency, Ottawa, ON K2H 8P9, Canada.
Glenn C TellingPrion Research Center, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80525.ORCID 0000-0002-6294-1805
Sylvie L BenestadWorld Organization for Animal Health Reference Laboratory for Chronic Wasting Disease, Norwegian Veterinary Institute, N-0106 Oslo, Norway.ORCID 0000-0002-3011-0484
Umberto AgrimiDepartment of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanità, 00161 Rome, Italy.
Istituto Superiore di Sanità · ITNorwegian Veterinary Institute · NOCanadian Food Inspection Agency · CAColorado State University · US

Funding

Zoonotic potential of CWD and influence of environmental contamination on prion propagationP01AI077774 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI Glenn C Telling · 2008 to 2026
$36.1M
Characterizing the strain and host range properties of prions causing emergent forms of chronic wasting diseaseR01NS109376 · NINDS · COLORADO STATE UNIVERSITY · PI TELLING, GLENN C · 2018 to 2022
$2.4M
Addressing the mechanisms of prion strain evolution and its effect on interspecies transmissionR01NS121682 · NINDS · COLORADO STATE UNIVERSITY · PI TELLING, GLENN C · 2021 to 2023
$1.5M
NIAID NIH HHS P01 AI077774NINDS NIH HHS R01 NS109376NINDS NIH HHS R01 NS121682
6 · The paper itself

Abstract

Chronic wasting disease (CWD) is a relentless epidemic disorder caused by infectious prions that threatens the survival of cervid populations and raises increasing public health concerns in North America. In Europe, CWD was detected for the first time in wild Norwegian reindeer (

Indexed as

Adaptation, PhysiologicalAnimalsArvicolinaeBrainNerve DegenerationNorth AmericaNorwayPhenotypePrionsSpecies SpecificityWasting Disease, ChronicPrionschronic wasting diseaseCWDprionsprion strainsTSE

Identifiers

PMID33229531
PMCPMC7733848
OpenAlexW3106938170

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.