ArticleProceedings of the National Academy of Sciences of the United States of America2020
Designer broad-spectrum polyimidazolium antibiotics.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 58 citations in OpenAlex.
- Spatial Evolution of Antimicrobial Metallopolymers toward the Main Chain Topology.ACS central science · 2026Article
- Designing halogen-free metal-phenolic imidazolium poly(ionic liquids) with multi-functional antibacterial, anti-inflammatory and cell proliferation properties for infected wounds.RSC medicinal chemistry · 2025Article
- Biguanide-functionalized peptide mimics effectively combat drug-resistant ESKAPE pathogens and meningitis.Nature communications · 2025Article
- Poly(imidazolium ester) antibiotic forms intracellular polymer-nucleic acid biomolecular condensates and fight drug-resistant bacteria.Nature communications · 2025Article
- Biological Merits and Antibiofilm Mechanisms of Action of a Specially Designed Double-Shelled Microparticle.ACS omega · 2025Article
- Carbene formation as a mechanism for efficient intracellular uptake of cationic antimicrobial carbon acid polymers.Nature communications · 2025Article
- Green synthesis, characterization, and antimicrobial activity of silver nanoparticles from water-soluble fractions of Brazilian Kefir.Scientific reports · 2025Article
- Alkyl Pyridinol Compounds Exhibit Antimicrobial Effects against Gram-Positive Bacteria.Antibiotics (Basel, Switzerland) · 2024Article
- AI-guided few-shot inverse design of HDP-mimicking polymers against drug-resistant bacteria.Nature communications · 2024Article
- A dual-targeting antifungal is effective against multidrug-resistant human fungal pathogens.Nature microbiology · 2024Article
- Hydrogel dressings with intrinsic antibiofilm and antioxidative dual functionalities accelerate infected diabetic wound healing.Nature communications · 2024Article
- A hydrophilic polyimidazolium antibiotic targeting the membranes of Gram-negative bacteria.The Journal of antimicrobial chemotherapy · 2023Article
- Membrane Potential-Dependent Uptake of Cationic Oligoimidazolium Mediates Bacterial DNA Damage and Death.Antimicrobial agents and chemotherapy · 2023Article
- Shapeshifting bullvalene-linked vancomycin dimers as effective antibiotics against multidrug-resistant gram-positive bacteria.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Review
- Polyimidazolium Protects against an Invasive Clinical Isolate of Salmonella Typhimurium.Antimicrobial agents and chemotherapy · 2022Article
- Antibacterial and Angiogenic Poly(ionic liquid) Hydrogels.Gels (Basel, Switzerland) · 2022Article
- Polymers as advanced antibacterial and antibiofilm agents for direct and combination therapies.Chemical science · 2022Review
- Biodegradable polycaprolactone metallopolymer-antibiotic bioconjugates containing phenylboronic acid and cobaltocenium for antimicrobial application.Biomaterials science · 2021Article
Corrections and comments
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Authors and funding
22 authors at 7 institutions in 4 countries.
Funding
Abstract
For a myriad of different reasons most antimicrobial peptides (AMPs) have failed to reach clinical application. Different AMPs have different shortcomings including but not limited to toxicity issues, potency, limited spectrum of activity, or reduced activity in situ. We synthesized several cationic peptide mimics, main-chain cationic polyimidazoliums (PIMs), and discovered that, although select PIMs show little acute mammalian cell toxicity, they are potent broad-spectrum antibiotics with activity against even pan-antibiotic-resistant gram-positive and gram-negative bacteria, and mycobacteria. We selected PIM1, a particularly potent PIM, for mechanistic studies. Our experiments indicate PIM1 binds bacterial cell membranes by hydrophobic and electrostatic interactions, enters cells, and ultimately kills bacteria. Unlike cationic AMPs, such as colistin (CST), PIM1 does not permeabilize cell membranes. We show that a membrane electric potential is required for PIM1 activity. In laboratory evolution experiments with the gram-positive
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.