ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2021
Neuronal Firing and Waveform Alterations through Ictal Recruitment in Humans.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 34 citations in OpenAlex.
- Article
- Integrating data across oscillatory power bands predicts the seizure onset zone in focal epilepsies.Brain communications · 2026Article
- High density probes reveal medullary seizure and rapid medullary shutdown in a model of fatal apnea in seizure.Epilepsy research · 2025Article
- Cathodal weak direct current decreases epileptic excitability with reduced neuronal activity and enhanced delta oscillations.The Journal of physiology · 2025Article
- Article
- A selective small-molecule agonist of G protein-gated inwardly-rectifying potassium channels reduces epileptiform activity in mouse models of tumor-associated and provoked seizures.Neuropharmacology · 2025Article
- Cellular resolution contributions to ictal population signals.Epilepsia · 2024Article
- Glioma-Induced Alterations in Excitatory Neurons are Reversed by mTOR Inhibition.bioRxiv : the preprint server for biology · 2024Article
- Cell-type specific and multiscale dynamics of human focal seizures in limbic structures.Brain : a journal of neurology · 2023Article
- Seizure onset patterns predict outcome after stereo-electroencephalography-guided laser amygdalohippocampotomy.Epilepsia · 2023Article
- Spatiotemporal spike-centered averaging reveals symmetry of temporal and spatial components of the spike-LFP relationship during human focal seizures.Communications biology · 2023Article
- Involvement of GABAergic Interneuron Subtypes in 4-Aminopyridine-Induced Seizure-Like Events in Mouse Entorhinal CortexThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Distinct signatures of loss of consciousness in focal impaired awareness versus tonic-clonic seizures.Brain : a journal of neurology · 2023Article
- Single unit analysis and wide-field imaging reveal alterations in excitatory and inhibitory neurons in glioma.Brain : a journal of neurology · 2022Article
- Human interictal epileptiform discharges are bidirectional traveling waves echoing ictal discharges.eLife · 2022Article
- Microelectrode recordings in human epilepsy: a case for clinical translation.Brain communications · 2020Review
Corrections and comments
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Authors and funding
11 authors at 8 institutions in 2 countries.
Funding
Abstract
Analyzing neuronal activity during human seizures is pivotal to understanding mechanisms of seizure onset and propagation. These analyses, however, invariably using extracellular recordings, are greatly hindered by various phenomena that are well established in animal studies: changes in local ionic concentration, changes in ionic conductance, and intense, hypersynchronous firing. The first two alter the action potential waveform, whereas the third increases the "noise"; all three factors confound attempts to detect and classify single neurons. To address these analytical difficulties, we developed a novel template-matching-based spike sorting method, which enabled identification of 1239 single neurons in 27 patients (13 female) with intractable focal epilepsy, that were tracked throughout multiple seizures. These new analyses showed continued neuronal firing with widespread intense activation and stereotyped action potential alterations in tissue that was invaded by the seizure: neurons displayed increased waveform duration (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.