Evidence map›Paper›PMID 33229461›Full record

ArticleJournal of bacteriology2021

ClpX Is Essential and Activated by Single-Strand DNA Binding Protein in Mycobacteria.

Jemila C Kester, Olga Kandror, Tatos Akopian, Michael R Chase, Junhao Zhu, Eric J Rubin, Alfred L Goldberg, Sarah M Fortune

Open access · hybridAbstract read
In one paragraph

Article in Journal of bacteriology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.2field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Fluoride triggers lysis inProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. Microbiology spectrum · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Frontiers in cellular and infection microbiology · 2023
    Article
  11. Review
  12. The essentialScience advances · 2022
    Article
  13. Control of Toxin-Antitoxin Systems by Proteases inFrontiers in molecular biosciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Jemila C KesterDepartment of Immunology and Infectious Diseases, Harvard TH Chan School of Public Health, Boston, Massachusetts, USA.
Olga KandrorDepartment of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA.
Tatos AkopianDepartment of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA.
Michael R ChaseDepartment of Immunology and Infectious Diseases, Harvard TH Chan School of Public Health, Boston, Massachusetts, USA.
Junhao ZhuDepartment of Immunology and Infectious Diseases, Harvard TH Chan School of Public Health, Boston, Massachusetts, USA.
Eric J RubinDepartment of Immunology and Infectious Diseases, Harvard TH Chan School of Public Health, Boston, Massachusetts, USA.
Alfred L GoldbergDepartment of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA.
Sarah M FortuneDepartment of Immunology and Infectious Diseases, Harvard TH Chan School of Public Health, Boston, Massachusetts, USA sfortune@hsph.harvard.edu.
Harvard University · US

Funding

The roles of genes critical for growth under defined conditions in vitro or duriU19AI107774 · NIAID · HARVARD SCHOOL OF PUBLIC HEALTH · PI CARR, STEVEN A, FORTUNE, SARAH · 2013 to 2017
$13.2M
MOLECULAR CHAPERONES AND PROTEIN DEGRADATIONR01GM051923 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI GOLDBERG, ALFRED L · 1995 to 2020
$10.1M
Defining the role of ClpX in mycobacterial cell cycle progressionF31AI120616 · NIAID · HARVARD SCHOOL OF PUBLIC HEALTH · PI KESTER, JEMILA CAPLAN · 2015 to 2016
$65k
NIAID NIH HHS F31 AI120616NIAID NIH HHS U19 AI107774NIGMS NIH HHS R01 GM051923
6 · The paper itself

Abstract

The ClpP1P2 proteolytic complex is essential in

Indexed as

Adenosine TriphosphatasesBacterial ProteinsBinding SitesDNA, BacterialDNA-Binding ProteinsDNA ReplicationEndopeptidase ClpGene Expression Regulation, BacterialGene Expression Regulation, EnzymologicMycobacterium tuberculosisProtein BindingAdenosine TriphosphatasesBacterial ProteinsDNA, BacterialDNA-Binding ProteinsEndopeptidase Clpcell cycleDNA replicationmycobacteriaprotein degradation

Identifiers

PMID33229461
PMCPMC7847540
OpenAlexW3109970449

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.