Evidence map›Paper›PMID 33229378›Full record

ArticleBMJ open diabetes research & care2020

Multimethod, multidataset analysis reveals paradoxical relationships between sociodemographic factors, Hispanic ethnicity and diabetes.

Gabriel M Knight, Gabriela Spencer-Bonilla, David M Maahs, Manuel R Blum, Areli Valencia, Bongeka Z Zuma, Priya Prahalad, Ashish Sarraju, Fatima Rodriguez, David Scheinker

Open access · goldAbstract read
In one paragraph

Article in BMJ open diabetes research & care, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Place-based heterogeneity in lung transplant recipient outcomes.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Gabriel M KnightNorthwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Gabriela Spencer-BonillaDepartment of Medicine, Stanford University School of Medicine, Stanford, California, USA.
David M MaahsDivision of Pediatric Endocrinology, Stanford University School of Medicine, Stanford, California, USA.
Manuel R BlumDepartment of Medicine, Stanford University School of Medicine, Stanford, California, USA.
Areli ValenciaStanford University School of Medicine, Stanford, California, USA.
Bongeka Z ZumaStanford University School of Medicine, Stanford, California, USA.
Priya PrahaladDivision of Pediatric Endocrinology, Stanford University School of Medicine, Stanford, California, USA.
Ashish SarrajuDivision of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California, USA.
Fatima RodriguezDivision of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California, USA dscheink@stanford.edu frodrigu@stanford.edu.
David ScheinkerDivision of Pediatric Endocrinology, Stanford University School of Medicine, Stanford, California, USA dscheink@stanford.edu frodrigu@stanford.edu.ORCID 0000-0001-5885-8024
Stanford University · USNorthwestern University · USUniversity of Bern · CH

Funding

Stanford Islet Research CoreP30DK116074 · NIDDK · STANFORD UNIVERSITY · PI Seung K Kim · 2017 to 2026
$19.5M
Stanford Medicine Center for Longevity and Healthy Aging Research Education CoreP30AG059307 · NIA · STANFORD UNIVERSITY · PI PERIYAKOIL, VYJEYANTHI S, YESAVAGE, JEROME A · 2018 to 2025
$4.9M
Teamwork, Targets, Technology, and Tight Control in Newly Diagnosed Pediatric T1D: 4T StudyR18DK122422 · NIDDK · STANFORD UNIVERSITY · PI MAAHS, DAVID MATTHEW · 2020 to 2024
$3.2M
SURPASS: (Statin Use and Risk Prediction of Atherosclerotic Cardiovascular Disease in minority Subgroups)K01HL144607 · NHLBI · STANFORD UNIVERSITY · PI RODRIGUEZ, FATIMA · 2019 to 2023
$856k
NHLBI NIH HHS K01 HL144607NIA NIH HHS P30 AG059307NIDDK NIH HHS P30 DK116074NIDDK NIH HHS R18 DK122422
6 · The paper itself

Abstract

introductionPopulation-level and individual-level analyses have strengths and limitations as do 'blackbox' machine learning (ML) and traditional, interpretable models. Diabetes mellitus (DM) is a leading cause of morbidity and mortality with complex sociodemographic dynamics that have not been analyzed in a way that leverages population-level and individual-level data as well as traditional epidemiological and ML models. We analyzed complementary individual-level and county-level datasets with both regression and ML methods to study the association between sociodemographic factors and DM. RESEARCH DESIGN AND

methodsCounty-level DM prevalence, demographics, and socioeconomic status (SES) factors were extracted from the 2018 Robert Wood Johnson Foundation County Health Rankings and merged with US Census data. Analogous individual-level data were extracted from 2007 to 2016 National Health and Nutrition Examination Survey studies and corrected for oversampling with survey weights. We used multivariate linear (logistic) regression and ML regression (classification) models for county (individual) data. Regression and ML models were compared using measures of explained variation (area under the receiver operating characteristic curve (AUC) and R

resultsAmong the 3138 counties assessed, the mean DM prevalence was 11.4% (range: 3.0%-21.1%). Among the 12 824 individuals assessed, 1688 met DM criteria (13.2% unweighted; 10.2% weighted). Age, gender, race/ethnicity, income, and education were associated with DM at the county and individual levels. Higher county Hispanic ethnic density was negatively associated with county DM prevalence, while Hispanic ethnicity was positively associated with individual DM. ML outperformed regression in both datasets (mean R

conclusionsHispanic individuals are at higher risk of DM, while counties with larger Hispanic populations have lower DM prevalence. Analyses of population-level and individual-level data with multiple methods may afford more confidence in results and identify areas for further study.

Indexed as

Diabetes MellitusEthnicityHispanic or LatinoHumansNutrition SurveysSocioeconomic Factorsdiabetes mellitusethnic groupsinformaticsrisk factorstype 2

Identifiers

PMID33229378
PMCPMC7684662
OpenAlexW3109432273

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.