Evidence map›Paper›PMID 33229339›Full record

Trial reportCancer prevention research (Philadelphia, Pa.)2021

Effects of Supplemental Calcium and Vitamin D on Circulating Biomarkers of Gut Barrier Function in Patients with Colon Adenoma: A Randomized Clinical Trial.

Kelly Vermandere, Roberd M Bostick, Hao Q Tran, Andrew T Gewirtz, Elizabeth L Barry, Robin E Rutherford, March E Seabrook, Veronika Fedirko

Open access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Cancer prevention research (Philadelphia, Pa.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Kelly VermandereDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia.ORCID 0000-0003-1190-1560
Roberd M BostickDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia.ORCID 0000-0001-8626-4186
Hao Q TranCenter for Inflammation, Immunity, and Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, Georgia.
Andrew T GewirtzCenter for Inflammation, Immunity, and Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, Georgia.
Elizabeth L BarryDepartment of Epidemiology, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire.ORCID 0000-0001-9637-3036
Robin E RutherfordDivision of Digestive Diseases, Department of Medicine, Emory University, Atlanta, Georgia.
March E SeabrookConsultants in Gastroenterology, West Columbia, South Carolina.
Veronika FedirkoDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia. vfedirk@emory.edu.ORCID 0000-0002-7805-9913
Emory University · USGeorgia State University · USDartmouth College · USSimulConsult · US

Funding

Colorectal Chemoprevention with Calcium and Vitamin DR01CA098286 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BARON, JOHN ANTHONY · 2003 to 2015
$43.9M
Calcium/Vitamin D, Biomarkers & Colon Polyp PreventionR01CA114456 · NCI · EMORY UNIVERSITY · PI BOSTICK, ROBERD MANER · 2006 to 2008
$1.3M
Vitamin D3, Calcium and Biomarkers of Gut Barrier FunctionR21CA182752 · NCI · EMORY UNIVERSITY · PI FEDIRKO, VERONIKA · 2014 to 2015
$389k
Vitamin D3, Calcium and Inflammation, Immunomodulation and Colonic PermeabilityR03CA184578 · NCI · EMORY UNIVERSITY · PI FEDIRKO, VERONIKA · 2014 to 2015
$171k
NCI NIH HHS R01 CA098286NCI NIH HHS R01 CA114456NCI NIH HHS R03 CA184578NCI NIH HHS R21 CA182752
6 · The paper itself

Abstract

Gut barrier dysfunction promotes chronic inflammation, contributing to several gastrointestinal diseases, including colorectal cancer. Preliminary evidence suggests that vitamin D and calcium could prevent colorectal carcinogenesis, in part, by influencing gut barrier function. However, relevant human data are scarce. We tested the effects of supplemental calcium (1,200 mg/day) and/or vitamin D

Indexed as

Dietary SupplementsAdenomaAgedBiomarkers, TumorCalcium, DietaryCase-Control StudiesColonic NeoplasmsDouble-Blind MethodFemaleFollow-Up StudiesGastrointestinal TractHumansMaleMiddle AgedPermeabilityPrognosisBiomarkers, TumorCalcium, DietaryVitamin DVitamins

Identifiers

PMID33229339
PMCPMC8137511
OpenAlexW3109561964

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.