SynthesisBiological psychiatry. Cognitive neuroscience and neuroimaging2021
Cortical Auditory Processing of Simple Stimuli Is Altered in Autism: A Meta-analysis of Auditory Evoked Responses.
Synthesis in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 3 syntheses or guidelines pooled it, 72 citations in OpenAlex.
- Neurophysiological alterations during sensory processing in autism - a meta-analysis.European child & adolescent psychiatry · 2026Pooled it
- Characterizing Interoceptive Differences in Autism: A Systematic Review and Meta-analysis of Case-control Studies.Journal of autism and developmental disorders · 2023Pooled it
- Prevalence of Decreased Sound Tolerance (Hyperacusis) in Individuals With Autism Spectrum Disorder: A Meta-Analysis.Ear and hearingPooled it
- Towards precision psychiatry: initial foundations and future directions.Nature reviews. Drug discovery · 2026Review
- Self-vocalizations activate the developing auditory cortex via an intracortical pathway.Science advances · 2026Article
- Elevated brain glutamine levels in adults with autism spectrum disorder: A 7T MRS study.Molecular psychiatry · 2026Article
- Comparative study of ERP habituation to tones and fearful vocalizations in autism spectrum disorders: a translational biomarker for sensory hypersensitivity.Molecular psychiatry · 2026Article
- Lower Cortical Activation and Altered Functional Connectivity Characterize Passive Auditory Spatial Attention in ASD.Autism research : official journal of the International Society for Autism Research · 2025Article
- Phenotypic variation in neural sensory processing by deletion size, age, and sex in Phelan-McDermid syndrome.Journal of neurodevelopmental disorders · 2025Article
- Testing the auditory steady-state response (ASSR) to 40-Hz and 27-Hz click trains in children with autism spectrum disorder and their first-degree biological relatives: A high-density electroencephalographic (EEG) study.bioRxiv : the preprint server for biology · 2025Article
- Lower cortical activation and altered functional connectivity characterize passive auditory spatial attention in ASD.bioRxiv : the preprint server for biology · 2025Article
- Nutritional Intake and Sensory Processing in School-Aged Children with Autism Spectrum Disorder.Nutrients · 2025Article
- How auditory processing influences the autistic profile: A review.Autism research : official journal of the International Society for Autism Research · 2024Review
- Where do neurodevelopmental conditions fit in transdiagnostic psychiatric frameworks? Incorporating a new neurodevelopmental spectrum.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2024Article
- The Effect of Attention on Auditory Processing in Adults on the Autism Spectrum.Journal of autism and developmental disorders · 2024Article
- Cortical dysmorphology and reduced cortico-collicular projections in an animal model of autism spectrum disorder.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- No Differences in Auditory Steady-State Responses in Children with Autism Spectrum Disorder and Typically Developing Children.Journal of autism and developmental disorders · 2024Article
- Vocal Emotion Recognition in Autism: Behavioral Performance and Event-Related Potential (ERP) Response.Journal of autism and developmental disorders · 2024Article
- "Neural Noise" in Auditory Responses in Young Autistic and Neurotypical Children.Journal of autism and developmental disorders · 2024Article
- Bringing the autistic lifeworld to supportive technology design: an enactive approach.CoDesign : international journal of cocreation in design and the arts · 2024Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundAuditory perceptual abnormalities are common in persons on the autism spectrum. The neurophysiologic underpinnings of these differences have frequently been studied using auditory event-related potentials (ERPs) and event-related magnetic fields (ERFs). However, no study to date has quantitatively synthesized this literature to determine whether early auditory ERP/ERF latencies or amplitudes in autistic persons differ from those of typically developing control subjects.
methodsWe searched PubMed and ProQuest for studies comparing 1) latencies/amplitudes of P1/M50, N1b, N1c, M100, P2/M200, and/or N2 ERP/ERF components evoked by pure tones and 2) paired-click sensory gating (P1/N1b amplitude suppression) in autistic individuals and typically developing control subjects. Effects were synthesized using Bayesian 3-level meta-analysis.
resultsIn response to pure tones, autistic individuals exhibited prolonged P1/M50 latencies (g = 0.341 [95% credible interval = 0.166, 0.546]), prolonged M100 latencies (g = 0.319 [0.093, 0.550]), reduced N1c amplitudes (g = -0.812 [-1.278, -0.187]), and reduced N2 amplitudes (g = -0.374 [-0.633, -0.179]). There were no practically significant group differences in P2/M200 latencies, N2 latencies, P1/M50 amplitudes, N1b amplitudes, M100 amplitudes, or P2/M200 amplitudes. Paired-click sensory gating was also reduced in autistic individuals (g = -0.389 [-0.619, -0.112]), although this effect was primarily driven by smaller responses to the first click stimulus.
conclusionsRelative to typically developing control subjects, autistic individuals demonstrate multiple alterations in early cortical auditory processing of simple stimuli. However, most group differences were modest in size and based on small numbers of heterogeneous studies with variable quality. Future work is necessary to understand whether these neurophysiologic measures can predict clinically meaningful outcomes or serve as stratification biomarkers for the autistic population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.