ArticleSchizophrenia research2021
Dynamic causal modeling of eye gaze processing in schizophrenia.
Article in Schizophrenia research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 31 citations in OpenAlex.
- Cognitive Mechanisms of Aberrant Self-Referential Social Perception in Psychosis and Bipolar Disorder: Insights From Computational Modeling.Schizophrenia bulletin · 2026Article
- Examining the joint and unique contributions of contour integration and visuospatial memory to altered eye gaze perception in schizophrenia.Schizophrenia research · 2025Article
- Monotonicity in graph theoretic summaries of fMRI data acquired during human learning.Frontiers in human neuroscience · 2025Article
- The overlap across psychotic disorders: A functional network connectivity analysis.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2024Article
- The importance of covert memory consolidation in schizophrenia: Dysfunctional network profiles of the hippocampus and the dorsolateral prefrontal cortex.Psychiatry research. Neuroimaging · 2024Article
- Aberrant Effective Connectivity During Eye Gaze Processing Is Linked to Social Functioning and Symptoms in Schizophrenia.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2023Article
- Task-residual effective connectivity of motor network in transient ischemic attack.Communications biology · 2023Article
- Learning without contingencies: A loss of synergy between memory and reward circuits in schizophrenia.Schizophrenia research · 2023Article
- Neurobehavioral indices of gaze perception are associated with social cognition across schizophrenia patients and healthy controls.Journal of psychopathology and clinical science · 2023Article
- Reductions in regional theta power and fronto-parietal theta-gamma phase-amplitude coupling during gaze processing in bipolar disorder.Psychiatry research. Neuroimaging · 2023Article
- Evidence for embracing normative modeling.eLife · 2023Article
- The topology, stability, and instability of learning-induced brain network repertoires in schizophrenia.Network neuroscience (Cambridge, Mass.) · 2023Article
- Antivax attitude in the general population along the autism-schizophrenia continuum and the impact of socio-demographic factors.Frontiers in psychology · 2023Article
- Article
- Sustained attention induces altered effective connectivity of the ascending thalamo-cortical relay in obsessive-compulsive disorder.Frontiers in psychiatry · 2022Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundAbnormal eye gaze perception is related to symptoms and social functioning in schizophrenia. However, little is known about the brain network mechanisms underlying these abnormalities. Here, we employed dynamic causal modeling (DCM) of fMRI data to discover aberrant effective connectivity within networks associated with eye gaze processing in schizophrenia.
methodsTwenty-seven patients (schizophrenia/schizoaffective disorder, SZ) and 22 healthy controls (HC) completed an eye gaze processing task during fMRI. Participants viewed faces with different gaze angles and performed explicit gaze discrimination (Gaze: "Looking at you?" yes/no) or implicit gaze processing (Gender: "male or female?"). Four brain regions, the secondary visual cortex (Vis), posterior superior temporal sulcus (pSTS), inferior parietal lobule (IPL), and posterior medial frontal cortex (pMFC) were identified as nodes for subsequent DCM analysis.
resultsSZ and HC showed similar generative model structure, but SZ showed altered connectivity for specific self-connections, inter-regional connections during all gaze processing (reduced excitatory bottom-up and enhanced inhibitory top-down connections), and modulation by explicit gaze discrimination (increased frontal inhibition of visual cortex). Altered effective connectivity was significantly associated with poorer social cognition and functioning.
conclusionsGeneral gaze processing in SZ is associated with distributed cortical dysfunctions and bidirectional connectivity between regions, while explicit gaze discrimination involves predominantly top-down abnormalities in the visual system. These results suggest plausible neural mechanisms underpinning gaze processing deficits and may serve as bio-markers for intervention.
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