ArticleBiological psychiatry2021
Elevated Polygenic Burden for Autism Spectrum Disorder Is Associated With the Broad Autism Phenotype in Mothers of Individuals With Autism Spectrum Disorder.
Article in Biological psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 59 citations in OpenAlex.
- Broader autism phenotype, the default mode network, and brain entropy: A network-level hypothesis.Research in neurodiversity · 2026Article
- Co-occurrence of rare variants implicates gene pairs in cytoskeletal pathways and is associated with increased severity in autism spectrum disorder.Genome biology · 2026Article
- Discourse Marker Use in Mothers of Autistic Individuals and FMR1 Premutation Carriers.Journal of autism and developmental disorders · 2026Article
- The impact of individual factors on linguistic alignment of autistic boys and their mothers.Autism : the international journal of research and practice · 2026Article
- Gaze-Speech Coordination During Narration in Autism Spectrum Disorder and First-Degree Relatives.Brain sciences · 2026Article
- Broad autism phenotype and parental personality in parents of preschoolers with autism: associations with social and behavioral profile.Frontiers in child and adolescent psychiatry · 2026Article
- Parental broad autism phenotype traits and executive function in families of children with autism spectrum disorder.Frontiers in psychiatry · 2026Article
- Narrative and visual attention in autism spectrum disorder: a cross-cultural perspective.Frontiers in psychiatry · 2026Article
- Systematic Review and Meta-Analysis: Phenotypic Correlates of the Autism Polygenic Score.JAACAP open · 2025Article
- Filled Pause Use in Autistic Adults and Their First-Degree Relatives: Gender Differences and Within-Family Associations.Journal of speech, language, and hearing research : JSLHR · 2025Article
- Narrative Ability in Autism and First-Degree Relatives.Journal of autism and developmental disorders · 2025Article
- Sex Differences in the Broad Autism Phenotype: Insights from the Australian Biobank.Journal of autism and developmental disorders · 2025Article
- Caregiver report of infant behavior associated with autism likelihood in first year of life.Pediatric research · 2025Article
- Pre-trained artificial intelligence language model represents pragmatic language variability central to autism and genetically related phenotypes.Autism : the international journal of research and practice · 2025Article
- Examining the Relationship Between Parental Broader Autism Phenotype Traits, Offspring Autism, and Parental Mental Health.Autism research : official journal of the International Society for Autism Research · 2025Article
- Context effects: discourse structure influences narrative ability in autism and first-degree relatives.Frontiers in psychiatry · 2025Article
- Exploring autism spectrum disorder and co-occurring trait associations to elucidate multivariate genetic mechanisms and insights.BMC psychiatry · 2024Article
- An Examination of Family Transmission of Traits Measured by the Social Responsiveness Scale-Short Form.Journal of autism and developmental disorders · 2024Article
- Evaluative contexts facilitate implicit mentalizing: relation to the broader autism phenotype and mental health.Scientific reports · 2024Article
- Parental Competences and Stress Levels in Mothers of Children with Autism Spectrum Disorders and Children Developing Neurotypically.Journal of clinical medicine · 2024Article
Corrections and comments
- Commented on by
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundAutism spectrum disorder (ASD) is a multifactorial neurodevelopmental disorder that encompasses a complex and heterogeneous set of traits. Subclinical traits that mirror the core features of ASD, referred to as the broad autism phenotype (BAP), have been documented repeatedly in unaffected relatives and are believed to reflect underlying genetic liability to ASD. The BAP may help inform the etiology of ASD by allowing the stratification of families into more phenotypically and etiologically homogeneous subgroups. This study explores polygenic scores related to the BAP.
methodsPhenotypic and genotypic information were obtained from 2614 trios from the Simons Simplex Collection. Polygenic scores of ASD (ASD-PGSs) were generated across the sample to determine the shared genetic overlap between the BAP and ASD. Maternal and paternal ASD-PGSs were explored in relation to BAP traits and their child's ASD symptomatology.
resultsMaternal pragmatic language was related to child's social communicative atypicalities. In fathers, rigid personality was related to increased repetitive behaviors in children. Maternal (but not paternal) ASD-PGSs were related to the pragmatic language and rigid BAP domains.
conclusionsAssociations emerged between parent and child phenotypes, with more associations emerging in mothers than in fathers. ASD-PGS associations emerged with BAP in mothers only, highlighting the potential for a female protective factor, and implicating the polygenic etiology of ASD-related phenotypes in the BAP.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.