Evidence map›Paper›PMID 33228553›Full record

ArticleBMC nephrology2020

Constitutive Atg5 overexpression in mouse bone marrow endothelial progenitor cells improves experimental acute kidney injury.

Daniel Patschan, Katrin Schwarze, Björn Tampe, Jan Ulrich Becker, Samy Hakroush, Oliver Ritter, Susann Patschan, Gerhard Anton Müller

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC nephrology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 9 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Daniel PatschanZentrum für Innere Medizin 1 - Kardiologie, Angiologie, Nephrologie, Klinikum Brandenburg, Medizinische Hochschule Brandenburg, Klinikum Brandenburg, Hochstraße 29, 14770, Brandenburg, Germany. daniel.patschan@mhb-fontane.de.ORCID 0000-0002-6914-5254
Katrin SchwarzeKlinik für Nephrologie und Rheumatologie, Universitätsmedizin Göttingen, Göttingen, Germany.
Björn TampeKlinik für Nephrologie und Rheumatologie, Universitätsmedizin Göttingen, Göttingen, Germany.
Jan Ulrich BeckerInstitut für Allgemeine Pathologie und Pathologische Anatomie, Universitätsklinikum Köln, Köln, Germany.
Samy HakroushInstitut für Pathologie, Universitätsmedizin Göttingen, Göttingen, Germany.
Oliver RitterZentrum für Innere Medizin 1 - Kardiologie, Angiologie, Nephrologie, Klinikum Brandenburg, Medizinische Hochschule Brandenburg, Klinikum Brandenburg, Hochstraße 29, 14770, Brandenburg, Germany.
Susann PatschanZentrum für Innere Medizin 1 - Kardiologie, Angiologie, Nephrologie, Klinikum Brandenburg, Medizinische Hochschule Brandenburg, Klinikum Brandenburg, Hochstraße 29, 14770, Brandenburg, Germany.
Gerhard Anton MüllerKlinik für Nephrologie und Rheumatologie, Universitätsmedizin Göttingen, Göttingen, Germany.
Universitätsmedizin Göttingen · DEUniversitätsklinikum Brandenburg an der Havel · DECentrum für Integrierte Onkologie · DE

Funding

Jackstädt-Stiftung DP
6 · The paper itself

Abstract

backgroundEndothelial Progenitor Cells have been shown as effective tool in experimental AKI. Several pharmacological strategies for improving EPC-mediated AKI protection were identified in recent years. Aim of the current study was to analyze consequences of constitutive Atg5 activation in murine EPCs, utilized for AKI therapy.

methodsIschemic AKI was induced in male C57/Bl6N mice. Cultured murine EPCs were systemically injected post-ischemia, either natively or after Atg5 transfection (Adenovirus-based approach). Mice were analyzed 48 h and 6 weeks later.

resultsBoth, native and transfected EPCs (EPCs

conclusionsConstitutive Atg5 activation augments AKI-protective effects of murine EPCs. The exact clinical consequences need to be determined.

Indexed as

Cell- and Tissue-Based TherapyAcute Kidney InjuryAnimalsAutophagyAutophagy-Related Protein 5Endothelial Progenitor CellsKidneyMaleMiceMice, Inbred C57BLAtg5 protein, mouseAutophagy-Related Protein 5AKIAtg5AutophagyEPCs

Identifiers

PMID33228553
PMCPMC7684746
OpenAlexW3106687354

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.