Evidence map›Paper›PMID 33228398›Full record

Observational studyCirculation. Heart failure2020

Association of Sedentary Time and Incident Heart Failure Hospitalization in Postmenopausal Women.

Michael J LaMonte, Joseph C Larson, JoAnn E Manson, John Bellettiere, Cora E Lewis, Andrea Z LaCroix, Jennifer W Bea, Karen C Johnson, Liviu Klein, Corinna A Noel and 3 more

Open access · bronzeAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Circulation. Heart failure, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Brazilian Guideline on Menopausal Cardiovascular Health - 2024.Arquivos brasileiros de cardiologia · 2024
    Guideline
  2. Article
  3. Article
  4. Brazilian Guideline on Menopausal Cardiovascular Health - 2024.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2024
    Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
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  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 10 institutions in 4 countries.

Michael J LaMonteDepartment of Epidemiology and Environmental Health, University at Buffalo, NY (M.J.L., J.W.-W.).
Joseph C LarsonFred Hutchinson Cancer Research Center, Seattle WA (J.C.L.).
JoAnn E MansonBrigham and Women's Hospital, Harvard Medical School, Boston, MA (J.E.M.).
John BellettiereDepartment of Family Medicine and Public Health, University of California San Diego (J.B., A.Z.L.).
Cora E LewisDepartment of Epidemiology, University of Alabama Birmingham (C.E.L.).
Andrea Z LaCroixDepartment of Family Medicine and Public Health, University of California San Diego (J.B., A.Z.L.).
Jennifer W BeaUniversity of Arizona Cancer Center, Tucson (J.W.B.).
Karen C JohnsonUniversity of Tennessee Health Sciences Center, Memphis (K.C.J).
Liviu KleinUniversity of California San Francisco School of Medicine (L.K.).
Corinna A NoelBrown University Warren Alpert School of Medicine, and School of Public Health, Providence, RI (C.A.N., C.B.E.).
Marcia L StefanickStanford University School of Medicine and Prevention Research Center, Palo Alto, CA (M.L.S.).
Jean Wactawski-WendeDepartment of Epidemiology and Environmental Health, University at Buffalo, NY (M.J.L., J.W.-W.).
Charles B EatonBrown University Warren Alpert School of Medicine, and School of Public Health, Providence, RI (C.A.N., C.B.E.).
Brown University · USUniversity at Buffalo, State University of New York · USUniversity of California System · USBrigham and Women's Hospital · USCape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa · ZAPalo Alto University · USUniversity of Alabama at Birmingham · USUniversity of Arizona · USUniversity of California, San Francisco · USUniversity of Tennessee Health Science Center · US

Funding

WHISH-2-Prevent Heart Failure StudyR01HL130591 · NHLBI · MEMORIAL HOSPITAL OF RHODE ISLAND · PI EATON, CHARLES B · 2016 to 2020
$3.1M
NHLBI NIH HHS HHSN268201600001CNHLBI NIH HHS HHSN268201600002CNHLBI NIH HHS HHSN268201600003CNHLBI NIH HHS HHSN268201600004CNHLBI NIH HHS HHSN268201600018CNHLBI NIH HHS R01 HL130591
6 · The paper itself

Abstract

backgroundThe 2018 US Physical Activity Guidelines recommend reducing sedentary behavior (SB) for cardiovascular health. SB's role in heart failure (HF) is unclear.

methodsWe studied 80 982 women in the Women's Health Initiative Observational Study, aged 50 to 79 years, who were without known HF and reported ability to walk ≥1 block unassisted at baseline. Mean follow-up was 9 years for physician-adjudicated incident HF hospitalization (1402 cases). SB was assessed repeatedly by questionnaire. Time-varying total SB was categorized according to awake time spent sitting or lying down (≤6.5, 6.6-9.5, >9.5 h/d); sitting time (≤4.5, 4.6-8.5, >8.5 h/d) was also evaluated. Hazard ratios and 95% CI were estimated using Cox regression.

resultsControlling for age, race/ethnicity, education, income, smoking, alcohol, menopausal hormone therapy, and hysterectomy status, higher HF risk was observed across incremental tertiles of time-varying total SB (hazard ratios [95% CI], 1.00 [referent], 1.15 [1.01-1.31], 1.42 [1.25-1.61], trend

conclusionsSB was associated with increased risk of incident HF hospitalization in postmenopausal women. Targeted efforts to reduce SB could enhance HF prevention in later life.

Indexed as

PostmenopauseSedentary BehaviorAgedFemaleHeart FailureHospitalizationHumansIncidenceMiddle AgedProspective StudiesSurveys and QuestionnairesUnited Statesheart diseaseheart failurehypertensionsedentary behaviorwomen

Identifiers

PMID33228398
PMCPMC7738397
OpenAlexW3107334517

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.