Evidence map›Paper›PMID 33228255›Full record

ArticleInternational journal of molecular sciences2020

The Effect of Deflazacort Treatment on the Functioning of Skeletal Muscle Mitochondria in Duchenne Muscular Dystrophy.

Mikhail V Dubinin, Eugeny Yu Talanov, Kirill S Tenkov, Vlada S Starinets, Natalia V Belosludtseva, Konstantin N Belosludtsev

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
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  9. BKPharmaceutics · 2022
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  11. Article
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  13. Article
  14. Article
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  16. Article
  17. Alisporivir Improves Mitochondrial Function in Skeletal Muscle ofInternational journal of molecular sciences · 2021
    Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Mikhail V DubininDepartment of Biochemistry, Cell Biology and Microbiology, Mari State University, pl. Lenina 1, 424001 Yoshkar-Ola, Russia.ORCID 0000-0002-7453-3390
Eugeny Yu TalanovLaboratory of Mitochondrial Transport, Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Institutskaya 3, 142290 Pushchino, Russia.
Kirill S TenkovDepartment of Biochemistry, Cell Biology and Microbiology, Mari State University, pl. Lenina 1, 424001 Yoshkar-Ola, Russia.
Vlada S StarinetsDepartment of Biochemistry, Cell Biology and Microbiology, Mari State University, pl. Lenina 1, 424001 Yoshkar-Ola, Russia.
Natalia V BelosludtsevaLaboratory of Mitochondrial Transport, Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Institutskaya 3, 142290 Pushchino, Russia.ORCID 0000-0001-5707-6557
Konstantin N BelosludtsevDepartment of Biochemistry, Cell Biology and Microbiology, Mari State University, pl. Lenina 1, 424001 Yoshkar-Ola, Russia.ORCID 0000-0001-5392-7035
Mari State University · RUInstitute of Theoretical and Experimental Biophysics · RU

Funding

Russian Science Foundation 18-75-00011Russian Science Foundation 20-75-10006
6 · The paper itself

Abstract

Duchenne muscular dystrophy (DMD) is a severe hereditary disease caused by a lack of dystrophin, a protein essential for myocyte integrity. Mitochondrial dysfunction is reportedly responsible for DMD. This study examines the effect of glucocorticoid deflazacort on the functioning of the skeletal-muscle mitochondria of dystrophin-deficient

Indexed as

Adenine Nucleotide Translocator 2Adenosine TriphosphateAnimalsCalciumCalcium ChannelsElectron Transport Complex IIIElectron Transport Complex IVGene Expression RegulationMaleMiceMice, Inbred C57BLMice, Inbred mdxMitochondrial Proton-Translocating ATPasesMitochondria, MuscleMuscle, SkeletalMuscular Dystrophy, DuchenneAdenine Nucleotide Translocator 2Adenosine TriphosphateCalciumCalcium ChannelsdeflazacortElectron Transport Complex IIIElectron Transport Complex IVmitochondrial calcium uniporterMitochondrial Proton-Translocating ATPasesPeptidyl-Prolyl Isomerase FPregnenedionesCa2+ uniporterdeflazacortDuchenne muscular dystrophymitochondriamitochondrial permeability transitionskeletal muscle

Identifiers

PMID33228255
PMCPMC7699511
OpenAlexW3102114696

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.