Evidence map›Paper›PMID 33228104›Full record

ArticleMolecules (Basel, Switzerland)2020

Rare-Earth Metal Complexes of the Antibacterial Drug Oxolinic Acid: Synthesis, Characterization, DNA/Protein Binding and Cytotoxicity Studies.

Ana-Madalina Maciuca, Alexandra-Cristina Munteanu, Mirela Mihaila, Mihaela Badea, Rodica Olar, George Mihai Nitulescu, Cristian V A Munteanu, Marinela Bostan, Valentina Uivarosi

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.8field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
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  8. Antioxidant and Cytotoxic Properties ofMolecules (Basel, Switzerland) · 2024
    Article
  9. Synthesis, Characterization and Cytotoxic Evaluation of New Pyrrolo[1,2-International journal of molecular sciences · 2023
    Article
  10. Computational and optoelectronic quantification of semi-conducting, warm ruby red color emanating EuPhotochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Ana-Madalina MaciucaDepartment of General and Inorganic Chemistry, Faculty of Pharmacy, Carol Davila University of Medicine and Pharmacy, 6 Traian Vuia St, 020956 Bucharest, Romania.
Alexandra-Cristina MunteanuDepartment of General and Inorganic Chemistry, Faculty of Pharmacy, Carol Davila University of Medicine and Pharmacy, 6 Traian Vuia St, 020956 Bucharest, Romania.
Mirela MihailaCenter of Immunology, Stefan S. Nicolau Institute of Virology, 285 Mihai Bravu Ave, 030304 Bucharest, Romania.
Mihaela BadeaDepartment of Inorganic Chemistry, Faculty of Chemistry, University of Bucharest, 90-92 Panduri Str, 050663 Bucharest, Romania.ORCID 0000-0002-4018-7610
Rodica OlarDepartment of Inorganic Chemistry, Faculty of Chemistry, University of Bucharest, 90-92 Panduri Str, 050663 Bucharest, Romania.ORCID 0000-0002-4208-0972
George Mihai NitulescuDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Carol Davila University of Medicine and Pharmacy, 6 Traian Vuia Str, 020956 Bucharest, Romania.ORCID 0000-0002-2978-8052
Cristian V A MunteanuDepartment of Bioinformatics and Structural Biochemistry, Institute of Biochemistry of the Romanian Academy (IBRA), 296 Spl. Independenţei, 060031 Bucharest, Romania.ORCID 0000-0002-2998-0458
Marinela BostanCenter of Immunology, Stefan S. Nicolau Institute of Virology, 285 Mihai Bravu Ave, 030304 Bucharest, Romania.ORCID 0000-0003-3050-6486
Valentina UivarosiDepartment of General and Inorganic Chemistry, Faculty of Pharmacy, Carol Davila University of Medicine and Pharmacy, 6 Traian Vuia St, 020956 Bucharest, Romania.ORCID 0000-0002-7165-5069
Carol Davila University of Medicine and Pharmacy · ROUniversity of Bucharest · ROInstitute of Biochemistry · RO

Funding

National Council for Higher Education, Ministry of National Education (Romania) PN-III-P1-1.1-PD-2019-1242, PN-III-P1-1.1-PD-2019-1312
6 · The paper itself

Abstract

"Drug repositioning" is a current trend which proved useful in the search for new applications for existing, failed, no longer in use or abandoned drugs, particularly when addressing issues such as bacterial or cancer cells resistance to current therapeutic approaches. In this context, six new complexes of the first-generation quinolone oxolinic acid with rare-earth metal cations (Y

Indexed as

Anti-Bacterial AgentsCell DeathCell Line, TumorCoordination ComplexesDensity Functional TheoryDNAFluorescenceHumansHuman Umbilical Vein Endothelial CellsInhibitory Concentration 50KineticsMetals, Rare EarthMolecular ConformationOxolinic AcidProtein BindingSerum Albumin, HumanAnti-Bacterial Agentscalf thymus DNACoordination ComplexesDNAMetals, Rare EarthOxolinic AcidSerum Albumin, HumananticancerDNA bindingdrug repositioningoxolinic acidquinolonerare-earth metal ionsserum proteins

Identifiers

PMID33228104
PMCPMC7699381
OpenAlexW3103985295

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.