ReviewPharmaceutics2020
The Current Status of Clinical Research Involving Microneedles: A Systematic Review.
Review in Pharmaceutics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Immunogenicity, safety, usability and acceptability of microarray patches for vaccination: a systematic review and meta-analysis.BMJ global health · 2023Pooled it
- Delivery of liothyronine by microneedle patch for the treatment of hypothyroidism.Drug delivery and translational research · 2026Article
- Exploratory Prospective Assessment of Instrumental Skin Changes and Patient-Reported Outcomes After Microneedling of the Neck and Décolleté.Journal of clinical medicine · 2026Article
- Inactivated mycobacterium paragordonae delivered via microneedle patches as a novel tuberculosis booster vaccine.Human vaccines & immunotherapeutics · 2025Article
- (Re)evolution in nanoparticles-loaded microneedle delivery systems: are we getting closer to a clinical translation?Nanomedicine (London, England) · 2025Review
- Development of Rapidly Dissolving Microneedles Integrated with Valsartan-Loaded Nanoliposomes for Transdermal Drug Delivery: In Vitro and Ex Vivo Evaluation.Pharmaceutics · 2025Article
- Designing Multifunctional Microneedles in Biomedical Engineering: Materials, Methods, and Applications.International journal of nanomedicine · 2025Review
- Advances and Challenges of Microneedle Assisted Drug Delivery for Biomedicals Applications: A Review.Current pharmaceutical biotechnology · 2025Review
- Revolutionizing Eye Care: Exploring the Potential of Microneedle Drug Delivery.Pharmaceutics · 2024Review
- Clinical efficacy of intradermal type I collagen injections in treating skin photoaging in patients from high-altitude areas.World journal of clinical cases · 2024Article
- Designing a Placebo Microneedle Stamp: Modeling and Validation in a Clinical Control Trial.Pharmaceutics · 2024Article
- Developing and validating a scale to measure the perceptions of safety, usability and acceptability of microarray patches for vaccination: a study protocol.Therapeutic advances in vaccines and immunotherapy · 2024Article
- Microneedles and Their Application in Transdermal Delivery of Antihypertensive Drugs-A Review.Pharmaceutics · 2023Review
- Current and next-generation formulation strategies for inactivated polio vaccines to lower costs, increase coverage, and facilitate polio eradication.Human vaccines & immunotherapeutics · 2022Review
- Usability, acceptability, and feasibility of a High-Density Microarray Patch (HD-MAP) applicator as a delivery method for vaccination in clinical settings.Human vaccines & immunotherapeutics · 2022Article
- Sugar-Triggered Burst Drug Releasing Poly-Lactic Acid (PLA) Microneedles and Its Fabrication Based on Solvent-Casting Approach.Pharmaceutics · 2022Article
- Prevention of Ageing-The Role of Micro-Needling in Neck and Cleavage Rejuvenation: A Narrative Review.International journal of environmental research and public health · 2022Review
- Potential of Microneedle Systems for COVID-19 Vaccination: Current Trends and Challenges.Pharmaceutics · 2022Review
- Innovations in vaccine delivery: increasing access, coverage, and equity and lessons learnt from measles and rubella elimination.Drug delivery and translational research · 2022Article
- Microneedle-Based Vaccine Delivery: Review of an Emerging Technology.AAPS PharmSciTech · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
In recent years, a number of clinical trials have been published on the efficacy and safety of drug delivery using microneedles (MNs). This review aims to systematically summarize and analyze the current evidence including the clinical effect and safety of MNs. Three electronic databases, including PubMed, were used to search the literature for randomized controlled trials (RCTs) and clinical controlled trials (CCTs) that evaluated the therapeutic efficacy of MNs from their inception to 28 June 2018. Data were extracted according to the characteristics of study subjects; disorder, types, and details of the intervention (MNs) and control groups; outcome measurements; effectiveness; and incidence of adverse events (AEs). Overall, 31 RCTs and seven CCTs met the inclusion criteria. Although MNs were commonly used in skin-related studies, evaluating the effects of MNs was difficult because many studies did not provide adequate comparison values between groups. For osteoporosis treatment, vaccine, and insulin delivery studies, MNs were comparable to or more effective than the gold standard. Regarding the safety of MNs, most AEs reported in each study were minor (grade 1 or 2). A well-designed RCT is necessary to clearly evaluate the effectiveness of MNs in the future.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.