Evidence map›Paper›PMID 33228031›Full record

ArticleInternational journal of molecular sciences2020

The Role of Cholesterol on Triterpenoid Saponin-Induced Endolysosomal Escape of a Saporin-Based Immunotoxin.

Wendy S Smith, David A Johnston, Harrison J Wensley, Suzanne E Holmes, Sopsamorn U Flavell, David J Flavell

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Wendy S SmithThe Simon Flavell Leukaemia Research Laboratory, Southampton General Hospital, Southampton SO16 6YD, UK.ORCID 0000-0002-2413-6717
David A JohnstonBiomedical Imaging Unit, University of Southampton Faculty of Medicine, Southampton General Hospital, Southampton SO16 6YD, UK.
Harrison J WensleyThe Simon Flavell Leukaemia Research Laboratory, Southampton General Hospital, Southampton SO16 6YD, UK.
Suzanne E HolmesThe Simon Flavell Leukaemia Research Laboratory, Southampton General Hospital, Southampton SO16 6YD, UK.
Sopsamorn U FlavellThe Simon Flavell Leukaemia Research Laboratory, Southampton General Hospital, Southampton SO16 6YD, UK.
David J FlavellThe Simon Flavell Leukaemia Research Laboratory, Southampton General Hospital, Southampton SO16 6YD, UK.ORCID 0000-0001-7145-4737
Southampton General Hospital · GB

Funding

Leukaemia Busters LB20/1
6 · The paper itself

Abstract

Cholesterol seems to play a central role in the augmentation of saporin-based immunotoxin (IT) cytotoxicity by triterpenoid saponins. Endolysosomal escape has been proposed as one mechanism for the saponin-mediated enhancement of targeted toxins. We investigated the effects of lipid depletion followed by repletion on

Indexed as

ADP-ribosyl Cyclase 1Cell Line, TumorCell MembraneCell Membrane PermeabilityCholesterolCholesterol, LDLDose-Response Relationship, DrugEndosomesFluoresceinsFluorescent DyesHumansImmunotoxinsLymphocytesLysosomesMembrane GlycoproteinsSaponinsADP-ribosyl Cyclase 1alexa fluor 488CD38 protein, humanCholesterolCholesterol, LDLFluoresceinsFluorescent DyesImmunotoxinsMembrane GlycoproteinsSaponinsSaporinsSulfonic AcidsTriterpenesaugmentationcholesterolendosomal escapeimmunotoxinsaponinsaporin

Identifiers

PMID33228031
PMCPMC7699356
OpenAlexW3105342413

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.