Evidence map›Paper›PMID 33228018›Full record

ArticleInternational journal of molecular sciences2020

An Exon-Specific Small Nuclear U1 RNA (ExSpeU1) Improves Hepatic OTC Expression in a Splicing-Defective

Dario Balestra, Mattia Ferrarese, Silvia Lombardi, Nicole Ziliotto, Alessio Branchini, Naomi Petersen, Piter Bosma, Mirko Pinotti, Stan F J van de Graaf

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. In-depth analysis ofFrontiers in pediatrics · 2024
    Article
  7. Development of Engineered-U1 snRNA Therapies: Current Status.International journal of molecular sciences · 2023
    Review
  8. Counteracting the Common Shwachman-Diamond Syndrome-CausingInternational journal of molecular sciences · 2023
    Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Dario BalestraDepartment of Life Sciences and Biotechnology and LTTA, University of Ferrara, 44121 Ferrara, Italy.ORCID 0000-0002-6675-9429
Mattia FerrareseDepartment of Life Sciences and Biotechnology and LTTA, University of Ferrara, 44121 Ferrara, Italy.
Silvia LombardiDepartment of Life Sciences and Biotechnology and LTTA, University of Ferrara, 44121 Ferrara, Italy.ORCID 0000-0003-2918-4010
Nicole ZiliottoDepartment of Life Sciences and Biotechnology and LTTA, University of Ferrara, 44121 Ferrara, Italy.ORCID 0000-0003-1007-7266
Alessio BranchiniDepartment of Life Sciences and Biotechnology and LTTA, University of Ferrara, 44121 Ferrara, Italy.ORCID 0000-0002-6113-2694
Naomi PetersenTytgat Institute for Liver and Intestinal Research and Department of Gastroenterology and Hepatology, Amsterdam UMC, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.
Piter BosmaTytgat Institute for Liver and Intestinal Research and Department of Gastroenterology and Hepatology, Amsterdam UMC, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.
Mirko PinottiDepartment of Life Sciences and Biotechnology and LTTA, University of Ferrara, 44121 Ferrara, Italy.ORCID 0000-0002-4114-7055
Stan F J van de GraafTytgat Institute for Liver and Intestinal Research and Department of Gastroenterology and Hepatology, Amsterdam UMC, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.ORCID 0000-0003-4238-4359
University of Ferrara · ITAmsterdam University Medical Centers · NL

Funding

AFM telethon AFM#21527the Netherlands Organization for Scientific Research VIDI 91713319
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

RNA SplicingAnimalsBase SequenceDependovirusDisease Models, AnimalExonsGenetic TherapyGenetic VectorsHumansIntronsLiverMaleMiceMice, TransgenicMutationOrnithine CarbamoyltransferaseOrnithine CarbamoyltransferaseRNA, Small NuclearRNA Splice SitesU1 small nuclear RNAAAVmiceornithine transcarbamylase deficiencyOTCDsplicingU1

Identifiers

PMID33228018
PMCPMC7699343
OpenAlexW3103991856

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.