Evidence map›Paper›PMID 33227989›Full record

ArticleGenes2020

SWI/SNF Alterations in Squamous Bladder Cancers.

Fabian Achenbach, Michael Rose, Nadina Ortiz-Brüchle, Lancelot Seillier, Ruth Knüchel, Veronika Weyerer, Arndt Hartmann, Ronja Morsch, Angela Maurer, Thorsten H Ecke and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
  3. The Role of SWI/SNF Complex in Bladder Cancer.Journal of cellular and molecular medicine · 2025
    Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Fabian AchenbachInstitute of Pathology, RWTH Aachen University, Pauwelsstrasse 30, 52074 Aachen, Germany.
Michael RoseInstitute of Pathology, RWTH Aachen University, Pauwelsstrasse 30, 52074 Aachen, Germany.
Nadina Ortiz-BrüchleInstitute of Pathology, RWTH Aachen University, Pauwelsstrasse 30, 52074 Aachen, Germany.ORCID 0000-0002-8923-2726
Lancelot SeillierInstitute of Pathology, RWTH Aachen University, Pauwelsstrasse 30, 52074 Aachen, Germany.ORCID 0000-0001-6704-2422
Ruth KnüchelInstitute of Pathology, RWTH Aachen University, Pauwelsstrasse 30, 52074 Aachen, Germany.
Veronika WeyererInstitute of Pathology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.
Arndt HartmannInstitute of Pathology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.
Ronja MorschDepartment of Urology, RWTH Aachen University, 52074 Aachen, Germany.
Angela MaurerInstitute of Pathology, RWTH Aachen University, Pauwelsstrasse 30, 52074 Aachen, Germany.
Thorsten H EckeDepartment of Urology, Helios Clinic, 15526 Bad Saarow, Germany.ORCID 0000-0002-0787-2763
Stefan GarczykInstitute of Pathology, RWTH Aachen University, Pauwelsstrasse 30, 52074 Aachen, Germany.
Nadine T GaisaInstitute of Pathology, RWTH Aachen University, Pauwelsstrasse 30, 52074 Aachen, Germany.ORCID 0000-0002-4762-3964
RWTH Aachen University · DEFriedrich-Alexander-Universität Erlangen-Nürnberg · DEHelios Hospital Bad Saarow · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dysfunction of the SWI/SNF complex has been observed in various cancers including urothelial carcinomas. However, the clinical impact of the SWI/SNF complex in squamous-differentiated bladder cancers (sq-BLCA) remains unclear. Therefore, we aimed to analyze potential expression loss and genetic alterations of (putative) key components of the SWI/SNF complex considering the co-occurrence of genetic driver mutations and PD-L1 expression as indicators for therapeutic implications. Assessment of

Indexed as

AdultAgedAged, 80 and overB7-H1 AntigenCarcinoma, Squamous CellChromosomal Proteins, Non-HistoneDNA-Binding ProteinsDNA HelicasesFemaleHumansMaleMiddle AgedNuclear ProteinsSMARCB1 ProteinTissue Array AnalysisTranscription FactorsARID1A protein, humanB7-H1 AntigenBANF1 protein, humanCD274 protein, humanChromosomal Proteins, Non-HistoneDNA-Binding ProteinsDNA HelicasesNuclear ProteinsSMARCA2 protein, humanSMARCA4 protein, humanSMARCB1 ProteinSMARCB1 protein, humanSMARCC1 protein, humanSMARCC2 protein, humanSWI-SNF-B chromatin-remodeling complexTranscription FactorsARID1Aimmune checkpoint inhibitorssquamous bladder cancerSWI/SNF complex

Identifiers

PMID33227989
PMCPMC7699259
OpenAlexW3100003962

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.