Evidence map›Paper›PMID 33227981›Full record

ArticleInternational journal of molecular sciences2020

Suppression of Non-Random Fertilization by MHC Class I Antigens.

Junki Kamiya, Woojin Kang, Keiichi Yoshida, Ryota Takagi, Seiya Kanai, Maito Hanai, Akihiro Nakamura, Mitsutoshi Yamada, Yoshitaka Miyamoto, Mami Miyado and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Effects of nTiOToxics · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 1 country.

Junki KamiyaLaboratory of Regulatory Biology, Department of Life Sciences, School of Agriculture, Meiji University, Kanagawa 214-8571, Japan.
Woojin KangDepartment of Reproductive Biology, National Research Institute for Child Health and Development, Tokyo 157-8535, Japan.ORCID 0000-0002-4880-3406
Keiichi YoshidaNext-generation Precision Medicine Research Center, Osaka International Cancer Institute, Osaka Prefectural Hospital Organization, Osaka 541-8567, Japan.
Ryota TakagiLaboratory of Regulatory Biology, Department of Life Sciences, School of Agriculture, Meiji University, Kanagawa 214-8571, Japan.
Seiya KanaiLaboratory of Regulatory Biology, Department of Life Sciences, School of Agriculture, Meiji University, Kanagawa 214-8571, Japan.
Maito HanaiLaboratory of Regulatory Biology, Department of Life Sciences, School of Agriculture, Meiji University, Kanagawa 214-8571, Japan.
Akihiro NakamuraDepartment of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo 160-8582, Japan.
Mitsutoshi YamadaDepartment of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo 160-8582, Japan.
Yoshitaka MiyamotoDepartment of Reproductive Biology, National Research Institute for Child Health and Development, Tokyo 157-8535, Japan.
Mami MiyadoDepartment of Molecular Endocrinology, National Research Institute for Child Health and Development, Tokyo 157-8535, Japan.
Yoko KurokiDepartment of Genome Medicine, National Research Institute for Child Health and Development, Tokyo 157-8535, Japan.
Yoshiki HayashiLife Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance (TARA), University of Tsukuba, Ibaraki 305-8577, Japan.
Akihiro UmezawaDepartment of Reproductive Biology, National Research Institute for Child Health and Development, Tokyo 157-8535, Japan.
Natsuko KawanoLaboratory of Regulatory Biology, Department of Life Sciences, School of Agriculture, Meiji University, Kanagawa 214-8571, Japan.
Kenji MiyadoDepartment of Reproductive Biology, National Research Institute for Child Health and Development, Tokyo 157-8535, Japan.ORCID 0000-0002-8339-6738
National Center For Child Health and Development · JPMeiji University · JPKeio University · JPOsaka International Cancer Institute · JPUniversity of Tsukuba · JP

Funding

JSPS KAKENHI JP16KK0192 and JP19H01067
6 · The paper itself

Abstract

Hermaphroditic invertebrates and plants have a self-recognition system on the cell surface of sperm and eggs, which prevents their self-fusion and enhances non-self-fusion, thereby contributing to genetic variation. However, the system of sperm-egg recognition in mammals is under debate. To address this issue, we explored the role of major histocompatibility complex class I (MHC class I, also known as histocompatibility 2-K

Indexed as

Sex RatioAnimalsbeta 2-MicroglobulinDNA-Binding ProteinsFemaleFertilityFertilization in VitroGene Expression RegulationHistocompatibility Antigens Class IHumansMaleMiceMice, KnockoutOvumSpermatozoaSperm Countbeta 2-MicroglobulinDNA-Binding ProteinsHistocompatibility Antigens Class IPfdn6 protein, mouseMHC class Inon-random fertilizationpolyspermy blocksex ratio

Identifiers

PMID33227981
PMCPMC7699254
OpenAlexW3103350990

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.