ArticleJournal of the National Cancer Institute2021
Poverty and Targeted Immunotherapy: Survival in Children's Oncology Group Clinical Trials for High-Risk Neuroblastoma.
Article in Journal of the National Cancer Institute, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06814795 (Feasibility of Medically Tailored Meals for Pediatric Populations at Risk for Disparities in Serious Illness Outcomes Due to Inequities in Social Drivers of Health), which is not on this map. Cited by 51 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Feasibility of Medically Tailored Meals for Pediatric Populations at Risk for Disparities in Serious Illness Outcomes Due to Inequities in Social Drivers of Health (MTM-Kids)
Who cites it
51 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.
- Social determinants of health and pediatric cancer survival: A systematic review.Pediatric blood & cancer · 2022Pooled it
- Relationship between sociodemographic characteristics at presentation and outcomes of provoked venous thromboembolism in United States children: a secondary analysis of the multinational Kids-duration of therapy for thrombosis trial.Research and practice in thrombosis and haemostasis · 2026Trial
- Supplemental Nutrition Assistance Program participation gaps within a pediatric leukemia clinical trial cohort.Pediatric blood & cancer · 2024Trial
- Providing Groceries and Transportation to Poverty-Exposed Pediatric Oncology Families: The PediCARE Pilot Randomized Clinical Trial.JAMA network open · 2024Trial
- Advances and disparities in survival of childhood and adolescent cancers.Journal of the National Cancer Institute · 2026Observational
- ASSIST: Refinement of a Benefits Navigator Intervention Among Low-Income Pediatric Oncology Families.Pediatric blood & cancer · 2026Article
- Identifying caregiver-reported modifiable barriers to pediatric oncology clinical trial enrollment and participation.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- Out-of-Pocket Costs and Health-Related Social Needs Among Households With Children.JAMA network open · 2026Article
- Collecting Social Determinants of Health in a Children's Oncology Group Trial for High-Risk Neuroblastoma.JAMA network open · 2026Article
- The Mediating Effect of Socioeconomic Status and Persistent Poverty on Racial and Ethnic Disparities in Pediatric Cancer Mortality in the United States.Cancer medicine · 2026Article
- Pediatric RISE: Development of a Poverty-Targeted Cash Support Intervention for Pediatric Cancer.Pediatric blood & cancer · 2026Article
- Development of a multidimensional disease burden assessment system for childhood neuroblastoma based on the social determinants of health theory.Frontiers in oncology · 2026Article
- Understanding access to novel high-cost cancer therapies across Canada: a national survey of pediatric oncology providers.Frontiers in pediatrics · 2026Article
- Identifying caregiver-reported modifiable barriers to pediatric oncology clinical trial enrollment and participation.Research square · 2025Article
- Impact of Genetic Ancestry on Genomics and Survival Outcomes in T-cell Acute Lymphoblastic Leukemia.Blood cancer discovery · 2025Article
- Food insecurity impacts neuroblastoma pathogenesis in murine xenograft tumor models.Communications biology · 2025Article
- Racial and Ethnic Survival Disparities Among Children With High-Risk Neuroblastoma: A Children's Oncology Group Report.JAMA network open · 2025Article
- Article
- Predictive model based on blood cell analysis and coagulation function indicators for neuroblastic tumors staging diagnosis.Frontiers in oncology · 2025Article
- Global, regional, and national burden of acute lymphoblastic leukemia in children: Epidemiological trends analysis from 1990 to 2021.iScience · 2024Article
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13 authors at 7 institutions in 1 country.
Funding
Abstract
backgroundWhether social determinants of health are associated with survival in the context of pediatric oncology-targeted immunotherapy trials is not known. We examined the association between poverty and event-free survival (EFS) and overall survival (OS) for children with high-risk neuroblastoma treated in targeted immunotherapy trials.
methodsWe conducted a retrospective cohort study of 371 children with high-risk neuroblastoma treated with GD2-targeted immunotherapy in the Children's Oncology Group trial ANBL0032 or ANBL0931 at a Pediatric Health Information System center from 2005 to 2014. Neighborhood poverty exposure was characterized a priori as living in a zip code with a median household income within the lowest quartile for the cohort. Household poverty exposure was characterized a priori as sole coverage by public insurance. Post hoc analyses examined the joint effect of neighborhood and household poverty using a common reference. All statistical tests were 2-sided.
resultsIn multivariable Cox regressions adjusted for disease and treatment factors, household poverty-exposed children experienced statistically significantly inferior EFS (hazard ratio [HR] = 1.90, 95% confidence interval [CI] = 1.28 to 2.82, P = .001) and OS (HR = 2.79, 95% CI = 1.63 to 4.79, P < .001) compared with unexposed children. Neighborhood poverty was not independently associated with EFS or OS. In post hoc analyses exploring the joint effect of neighborhood and household poverty, children with dual-poverty exposure (neighborhood poverty and household poverty) experienced statistically significantly inferior EFS (HR = 2.21, 95% CI = 1.48 to 3.30, P < .001) and OS (HR = 3.70, 95% CI = 2.08 to 6.59, P < .001) compared with the unexposed group.
conclusionsPoverty is independently associated with increased risk of relapse and death among neuroblastoma patients treated with targeted immunotherapy. Incorporation of social and environmental factors in future trials as health-care delivery intervention targets may increase the benefit of targeted therapies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.