ReviewPhysics in medicine and biology2021
Roadmap: proton therapy physics and biology.
Review in Physics in medicine and biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
74 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The current status of FLASH particle therapy: a systematic review.Physical and engineering sciences in medicine · 2023Pooled it
- A novel approach for spot boosting selection and treatment plan optimization to enhance prompt gamma monitoring of proton therapy.Physics and imaging in radiation oncology · 2026Article
- Development of a GPU-based dose calculation engine for MRI-guided proton therapy.Medical physics · 2026Article
- Factors associated with acute radiation-induced nocturia in localized prostate cancer treated with proton beam therapy.Journal of radiation research · 2026Article
- Study of prompt gamma and neutron emission for real-time range verification in proton and carbon-ion therapy.Medical physics · 2026Article
- Reduced beam time and distal linear energy transfer with mini-ridge filters in pencil beam scanning proton therapy.Physics and imaging in radiation oncology · 2026Article
- Impact of reduced robustness settings on the necessity for proton therapy treatment plan adaptation in head-and-neck cancer patients.Physics and imaging in radiation oncology · 2026Article
- Proton versus photon radiotherapy in adults with primary brain tumors evaluating functional survival: a phase 3 randomized controlled trial study protocol (PRIDE).Radiation oncology (London, England) · 2026Article
- Advances in proton therapy technology and global clinical applications.Frontiers in oncology · 2026Review
- Towards ultra-fast treatments: large energy acceptance beam delivery systems and opportunities for proton beam therapy.Frontiers in oncology · 2026Review
- Advancing proton therapy together: insights on practice, technology, and implementation.Technical innovations & patient support in radiation oncology · 2025Article
- Practical considerations for handling implants in proton therapy.Journal of applied clinical medical physics · 2025Article
- Comparison of cone beam computed tomography post-processing methods for online adaptive proton therapy of prostate cancer.Physics and imaging in radiation oncology · 2025Article
- Exploring the potential benefits of multi-field IMPT for stage I NSCLC SBRT: An in silico dosimetric comparison to IMRT and CyberKnife.Precision radiation oncology · 2025Article
- The effect of interfractional variation on delivered dose with ultrahypofractionated pencil beam scanning proton therapy for localized prostate cancer.Journal of applied clinical medical physics · 2025Article
- Differentiation Stage Predicts Radiosensitivity in Mesenchymal-Like Pancreatic Cancer.International journal of radiation oncology, biology, physics · 2025Article
- Advances in radiotherapy for mouth neoplasms: emerging technologies and future perspectives.Discover oncology · 2025Review
- Diffusion Schrödinger bridge models for high-quality MR-to-CT synthesis for proton treatment planning.Medical physics · 2025Article
- A proof-of-concept study of direct magnetic resonance imaging-based proton dose calculation for brain tumors via neural networks with Monte Carlo-comparable accuracy.Physics and imaging in radiation oncology · 2025Article
- Instantaneous in vivo distal edge verification in intensity-modulated proton therapy by means of PET imaging.Medical physics · 2025Article
14 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors.
Funding
Abstract
The treatment of cancer with proton radiation therapy was first suggested in 1946 followed by the first treatments in the 1950s. As of 2020, almost 200 000 patients have been treated with proton beams worldwide and the number of operating proton therapy (PT) facilities will soon reach one hundred. PT has long moved from research institutions into hospital-based facilities that are increasingly being utilized with workflows similar to conventional radiation therapy. While PT has become mainstream and has established itself as a treatment option for many cancers, it is still an area of active research for various reasons: the advanced dose shaping capabilities of PT cause susceptibility to uncertainties, the high degrees of freedom in dose delivery offer room for further improvements, the limited experience and understanding of optimizing pencil beam scanning, and the biological effect difference compared to photon radiation. In addition to these challenges and opportunities currently being investigated, there is an economic aspect because PT treatments are, on average, still more expensive compared to conventional photon based treatment options. This roadmap highlights the current state and future direction in PT categorized into four different themes, 'improving efficiency', 'improving planning and delivery', 'improving imaging', and 'improving patient selection'.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.