SynthesisInternational journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases2021
Severe COVID-19 Infection and Pediatric Comorbidities: A Systematic Review and Meta-Analysis.
Synthesis in International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 180 papers, 6 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
180 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Risk Factors for Pediatric Critical COVID-19: A Systematic Review and Meta-Analysis.Journal of the Pediatric Infectious Diseases Society · 2024Pooled it
- Evidence linking COVID-19 and the health/well-being of children and adolescents: an umbrella review.BMC medicine · 2024Pooled it
- Obesity as a risk factor for severe influenza infection in children and adolescents: a systematic review and meta-analysis.European journal of pediatrics · 2023Pooled it
- Obesity and COVID-19 in Children and Adolescents: Reciprocal Detrimental Influence-Systematic Literature Review and Meta-Analysis.International journal of environmental research and public health · 2022Pooled it
- SARS-CoV-2 Circulation in the School Setting: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2022Pooled it
- Coronavirus Disease 2019 (COVID-19) Vaccination for Children: Position Statement of Indian Academy of Pediatrics Advisory Committee on Vaccination and Immunization Practices.Indian pediatrics · 2022Guideline
- Incidence Rates of COVID-19-Associated Hospitalization and Risk Factors for Severe Disease Among American Indian and Alaska Native Persons in the Southwest USA and Alaska.Journal of racial and ethnic health disparities · 2026Observational
- Neurological and neurodevelopmental effects of Covid and MIS-C on children.Pediatric research · 2026Review
- Antibody repertoire associated with clinically diverse presentations of pediatric SARS-CoV-2 infection.Scientific reports · 2026Article
- Nutritional Status as a Severity Predictor in Critical Pediatric Patients With COVID-19.Pediatric pulmonology · 2026Observational
- Observational
- Risk factors for severe disease in children hospitalized with SARS-CoV-2 infection in China: a retrospective cohort study.BMC infectious diseases · 2025Article
- Disease Spectrum and Predictors of Prolonged Hospitalization in Lebanese Children With COVID-19.Cureus · 2025Article
- Factors influencing pediatric COVID-19 vaccination uptake: a quantitative investigation in the Philippines.BMC public health · 2025Article
- COVID-19-Related Healthcare Resource Utilisation and Costs in Paediatric Patients in Germany: A Population-Based Study.Advances in therapy · 2025Article
- Association Between Pre-Existing Conditions and COVID-19 Hospitalization, Intensive Care Services, and Mortality: A Cross-Sectional Analysis of an International Global Health Data Repository.Pathogens (Basel, Switzerland) · 2025Article
- Histopathological examination of lung from infant with lethal COVID-19 with special attention on pneumocytes type II and the immune infiltrate: a case study.Italian journal of pediatrics · 2025Article
- Article
- Hospitalization and Mortality in Brazilian Children and Adolescents Due to COVID-19: Retrospective Study.JMIR pediatrics and parenting · 2025Article
- A retrospective evaluation of SwePEWS use in paediatric patients with COVID-19 and RSV infection.Acta paediatrica (Oslo, Norway : 1992) · 2025Article
120 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThere is limited information on the severity of COVID-19 infection in children with comorbidities. We investigated the effects of pediatric comorbidities on COVID-19 severity by means of a systematic review and meta-analysis of published literature.
methodsPubMed, Embase, and Medline databases were searched for publications on pediatric COVID-19 infections published January 1
results42 studies containing 275,661 children without comorbidities and 9,353 children with comorbidities were included. Severe COVID-19 was present in 5.1% of children with comorbidities, and in 0.2% without comorbidities. Random-effects analysis revealed a higher risk of severe COVID-19 among children with comorbidities than for healthy children; relative risk ratio 1.79 (95% CI 1.27 - 2.51; I
conclusionsChildren with comorbidities have a higher risk of severe COVID-19 and associated mortality than children without underlying disease. Additional studies are required to further evaluate this relationship.
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Registered trials
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