Evidence map›Paper›PMID 33227491›Full record

ArticleNeurobiology of disease2021

Lateral habenula dysfunctions in Tm4sf2

Luca Murru, Luisa Ponzoni, Anna Longatti, Sara Mazzoleni, Giorgia Giansante, Silvia Bassani, Mariaelvina Sala, Maria Passafaro

Open access · goldAbstract read
In one paragraph

Article in Neurobiology of disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Loss of tetraspanin-7 expression reduces pancreatic β-cell exocytosis CaDiabetic medicine : a journal of the British Diabetic Association · 2022
    Article
  8. Editorial: The Habenula and Its Role in Neuropsychiatric Symptoms.Frontiers in behavioral neuroscience · 2022
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Luca MurruInstitute of Neuroscience, CNR, Milan 20129, Italy; NeuroMI Milan Center for Neuroscience, Università Milano-Bicocca, Milan 20126, Italy. Electronic address: luca.murru@in.cnr.it.
Luisa PonzoniDepartment of Medical Biotechnology and Translational Medicine, Università di Milano, Segrate, MI 20090, Italy.
Anna LongattiInstitute of Neuroscience, CNR, Milan 20129, Italy.
Sara MazzoleniInstitute of Neuroscience, CNR, Milan 20129, Italy; Department of Medical Biotechnology and Translational Medicine, Università di Milano, Segrate, MI 20090, Italy.
Giorgia GiansanteInstitute of Neuroscience, CNR, Milan 20129, Italy.
Silvia BassaniInstitute of Neuroscience, CNR, Milan 20129, Italy; NeuroMI Milan Center for Neuroscience, Università Milano-Bicocca, Milan 20126, Italy.
Mariaelvina SalaInstitute of Neuroscience, CNR, Milan 20129, Italy; NeuroMI Milan Center for Neuroscience, Università Milano-Bicocca, Milan 20126, Italy.
Maria PassafaroInstitute of Neuroscience, CNR, Milan 20129, Italy; NeuroMI Milan Center for Neuroscience, Università Milano-Bicocca, Milan 20126, Italy. Electronic address: maria.passafaro@in.cnr.it.
Neuroscience Institute · ITUniversity of Milan · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mutations in the TM4SF2 gene, which encodes TSPAN7, cause a severe form of intellectual disability (ID) often comorbid with autism spectrum disorder (ASD). Recently, we found that TM4SF2 loss in mice affects cognition. Here, we report that Tm4sf2

Indexed as

AnhedoniaAnimalsAutism Spectrum DisorderDepressionDisease Models, AnimalHabenulaIntellectual DisabilityMaleMAP Kinase Signaling SystemMembrane ProteinsMiceMice, KnockoutNerve Tissue ProteinsNeurodevelopmental DisordersNeuronsPotassium Channels, Voltage-GatedMembrane ProteinsNerve Tissue ProteinsPotassium Channels, Voltage-GatedProtein Kinase CTm4sf2 protein, mouseVoltage-Gated Sodium ChannelsAutism spectrum disorderIntellectual disabilityLateral habenulaNeurodevelopmental disordersTSPAN7

Identifiers

PMID33227491
PMCPMC7840593
OpenAlexW3099211784

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.