ArticleActa biomaterialia2021
Comparison of morphometric, structural, mechanical, and physiologic characteristics of human superficial femoral and popliteal arteries.
Article in Acta biomaterialia, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Biomechanical Characterization of Porcine Lower Limb Arteries for Preclinical Evaluation of Peripheral Vascular Devices.Annals of biomedical engineering · 2026Article
- Investigating the early diagnostic value of popliteal artery wall shear stress in lower extremity arterial disease in type 2 diabetes patients using color Doppler ultrasound combined with WSS quantitative analysis.Biomedical engineering online · 2026Article
- BIOMECHANICAL CHARACTERIZATION OF PORCINE LOWER LIMB ARTERIES FOR PRECLINICAL EVALUATION OF PERIPHERAL VASCULAR DEVICES.bioRxiv : the preprint server for biology · 2025Article
- EXPERIMENTAL CHARACTERIZATION OF BALLOON ANGIOPLASTY IN HUMAN FEMOROPOPLITEAL ARTERIES WITH DIFFERENT CALCIUM BURDENS.bioRxiv : the preprint server for biology · 2025Article
- Differential effects of demographics and risk factors on the nonlinear orthotropic mechanical properties of human femoropopliteal arteries.Biomechanics and modeling in mechanobiology · 2025Article
- From Bench Testing to Virtual Implantation: A Comparative Study Between Poly-l-Lactic Acid and Nickel-Titanium Braided Stents.International journal for numerical methods in biomedical engineering · 2025Article
- The Impact of Peripheral Vascular Motion on Acute Drug Retention of Intravascular Devices.Cardiovascular engineering and technology · 2025Article
- Large animal model of controlled peripheral artery calcification.Acta biomaterialia · 2025Article
- Cardiac implications of chicken wooden breast myopathy.Frontiers in physiology · 2025Article
- A viscoelastic constitutive framework for aging muscular and elastic arteries.Acta biomaterialia · 2024Article
- Treatment extent of femoropopliteal disease and clinical outcomes following endovascular therapy.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2024Article
- Sitting knee-flexion angle does not influence endothelial-dependent vasodilation in laboratory or free-living conditions.Vascular medicine (London, England) · 2024Article
- An optimized differential evolution algorithm for constitutive model fitting of arteries.Acta mechanica · 2024Article
- Mechanical, structural, and morphological differences in the iliac arteries.Journal of the mechanical behavior of biomedical materials · 2024Article
- Structural and Mechanical Properties of Human Superficial Femoral and Popliteal Arteries.Annals of biomedical engineering · 2024Review
- Mechanical, structural, and physiologic differences between above and below-knee human arteries.Acta biomaterialia · 2024Article
- Article
- Investigating Balloon-Vessel Contact Pressure Patterns in Angioplasty: In Silico Insights for Drug-Coated Balloons.Annals of biomedical engineering · 2023Article
- A viscoelastic constitutive model for human femoropopliteal arteries.Acta biomaterialia · 2023Article
- Histology Image Viewer and Converter (HIVC): A High-Speed Freeware Software to View and Convert Whole Slide Histology Images.Computer methods in biomechanics and biomedical engineering. Imaging & visualization · 2023Article
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Authors and funding
7 authors.
Funding
Abstract
Peripheral arterial disease differentially affects the superficial femoral (SFA) and the popliteal (PA) arteries, but their morphometric, structural, mechanical, and physiologic differences are poorly understood. SFAs and PAs from 125 human subjects (age 13-92, average 52±17 years) were compared in terms of radii, wall thickness, and opening angles. Structure and vascular disease were quantified using histology, mechanical properties were determined with planar biaxial extension, and constitutive modeling was used to calculate the physiologic stress-stretch state, elastic energy, and the circumferential physiologic stiffness. SFAs had larger radii than PAs, and both segments widened with age. Young SFAs were 5% thicker, but in old subjects the PAs were thicker. Circumferential (SFA: 96→193°, PA: 105→139°) and longitudinal (SFA: 139→306°, PA: 133→320°) opening angles increased with age in both segments. PAs were more diseased than SFAs and had 11% thicker intima. With age, intimal thickness increased 8.5-fold, but medial thickness remained unchanged (620μm) in both arteries. SFAs had 30% more elastin than the PAs, and its density decreased ~50% with age. SFAs were more compliant than PAs circumferentially, but there was no difference longitudinally. Physiologic circumferential stress and stiffness were 21% and 11% higher in the SFA than in the PA across all ages. The stored elastic energy decreased with age (SFA: 1.4→0.4kPa, PA: 2.5→0.3kPa). While the SFA and PA demonstrate appreciable differences, most of them are due to vascular disease. When pathology is the same, so are the mechanical properties, but not the physiologic characteristics that remain distinct due to geometrical differences.
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