Evidence map›Paper›PMID 33227311›Full record

ArticleJournal of molecular biology2021

ZZEF1 is a Histone Reader and Transcriptional Coregulator of Krüppel-Like Factors.

Yucong Yu, Adam Tencer, Hongwen Xuan, Tatiana G Kutateladze, Xiaobing Shi

Open access · greenAbstract read
In one paragraph

Article in Journal of molecular biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Histone Readers and Their Roles in Cancer.Cancer treatment and research · 2023
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Yucong YuCenter for Epigenetics, Van Andel Institute, Grand Rapids, MI 49503, USA.
Adam TencerDepartment of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Hongwen XuanCenter for Epigenetics, Van Andel Institute, Grand Rapids, MI 49503, USA.
Tatiana G KutateladzeDepartment of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, USA. Electronic address: tatiana.kutateladze@cuanschutz.edu.
Xiaobing ShiCenter for Epigenetics, Van Andel Institute, Grand Rapids, MI 49503, USA. Electronic address: Xiaobing.shi@vai.org.
Van Andel Institute · USUniversity of Colorado Anschutz Medical Campus · USUniversity of Colorado Denver · US

Funding

Targeting acetylated histone H4 by MLL4R01AG067664 · NIA · UNIVERSITY OF COLORADO DENVER · PI KUTATELADZE, TATIANA G · 2021 to 2025
$2.1M
Role of GAS41 in Human CancerR01CA204020 · NCI · VAN ANDEL RESEARCH INSTITUTE · PI SHI, XIAOBING · 2016 to 2020
$2.0M
Molecular analysis of ASH1LR01CA252707 · NCI · UNIVERSITY OF COLORADO DENVER · PI TATIANA G KUTATELADZE · 2020 to 2026
$1.9M
The role of JADE in HBO complexesR01HL151334 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI KUTATELADZE, TATIANA G · 2020 to 2023
$1.8M
Targeting acetylated histone H4 by MLL4R56AG067664 · NIA · UNIVERSITY OF COLORADO DENVER · PI KUTATELADZE, TATIANA G · 2020 to 2020
$512k
NCI NIH HHS R01 CA204020NCI NIH HHS R01 CA252707NHLBI NIH HHS R01 HL151334NIA NIH HHS R01 AG067664NIA NIH HHS R56 AG067664
6 · The paper itself

Abstract

The ZZ-type zinc finger and EF-hand domain protein 1 (ZZEF1) is a multidomain-containing protein. Mutations of ZZEF1 has been implicated in several kinds of human diseases such as diabetes and cancers. However, the function of the ZZEF protein remains largely unknown. Here we show that ZZEF1 functions as a histone H3 reader. The second ZZ domain of ZZEF1 (ZZEF1

Indexed as

Zinc FingersAmino Acid MotifsAmino Acid SequenceBinding SitesCell Line, TumorGene Expression RegulationHistonesHumansKruppel-Like Transcription FactorsModels, BiologicalProtein BindingProtein Interaction Domains and MotifsTranscription FactorsHistonesKruppel-Like Transcription FactorsTranscription FactorsH3KLF9Krüppel-like factorsZZ domainZZEF1

Identifiers

PMID33227311
PMCPMC8133392
OpenAlexW3102256471

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.