Evidence map›Paper›PMID 33226973›Full record

ArticleMedical science monitor : international medical journal of experimental and clinical research2020

Altered Brain Network Centrality in Patients with Adult Strabismus with Amblyopia: A Resting-State Functional Magnetic Resonance Imaging (fMRI) Study.

Kang-Rui Wu, Ya-Jie Yu, Li-Ying Tang, Si-Yi Chen, Meng-Yao Zhang, Tie Sun, Shi-Nan Wu, Kang Yu, Biao Li, Yi Shao

Open access · hybridAbstract read
In one paragraph

Article in Medical science monitor : international medical journal of experimental and clinical research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Amblyopia: progress and promise of functional magnetic resonance imaging.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2023
    Pooled it
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  8. [Abnormal spontaneous brain functional activity in adult patients with amblyopia: a resting-state functional magnetic resonance imaging study].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Kang-Rui WuDepartment of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China (mainland).
Ya-Jie YuDepartment of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China (mainland).
Li-Ying TangDepartment of Ophthalmology, Xiang'an Hospital of Xiamen University; Fujian Provincial Key Laboratory of Ophthalmology and Visual Science; Eye Institute of Xiamen University; Xiamen University School of Medicine, Xiamen, Fujian, China (mainland).
Si-Yi ChenDepartment of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China (mainland).
Meng-Yao ZhangDepartment of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China (mainland).
Tie SunDepartment of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China (mainland).
Shi-Nan WuDepartment of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China (mainland).
Kang YuDepartment of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China (mainland).
Biao LiDepartment of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China (mainland).
Yi ShaoDepartment of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China (mainland).
First Affiliated Hospital of Nanchang University · CNNanchang University · CNXiamen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND The aim of this study was to explore potential changes in brain function network activity in patients with adult strabismus with amblyopia (SA) using the voxel-wise degree centrality (DC) method. MATERIAL AND METHODS We enrolled 15 patients with SA (6 males, 9 females) and 15 sex-matched healthy controls (HCs). All subjects completed resting functional magnetic resonance imaging scans. Independent-sample t tests and receiver operating characteristic (ROC) curves were used to assess DC value differences between groups, and Pearson correlation analysis was performed to evaluate correlations between DC-changed brain regions and clinical data of patients with SA. RESULTS Compared with the HC group, DC values that were lower in patients with SA included the left middle frontal gyrus and bilateral angular gyri. Increases were observed in the left fusiform gyrus, right lingual gyrus, right middle occipital gyrus, right postcentral gyrus, and left paracentral lobule. However, DC values were not correlated with clinical manifestations. ROC curve analysis showed high accuracy. CONCLUSIONS We found abnormal neural activity in specific brain regions in patients with SA. Specifically, we observed significant changes in DC values compared to HCs. These changes may be useful to identify the specific mechanisms involved in brain dysfunction in SA.

Indexed as

Magnetic Resonance ImagingRestAdultAmblyopiaBrainCase-Control StudiesFemaleHumansMaleNerve NetROC CurveStrabismusYoung Adult

Identifiers

PMID33226973
PMCPMC7693780
OpenAlexW3105954866

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.