Evidence map›Paper›PMID 33226858›Full record

SynthesisAnnals of internal medicine2021

Are Financial Payments From the Pharmaceutical Industry Associated With Physician Prescribing? : A Systematic Review.

Aaron P Mitchell, Niti U Trivedi, Renee L Gennarelli, Susan Chimonas, Sara M Tabatabai, Johanna Goldberg, Luis A Diaz, Deborah Korenstein

Abstract readSystematic Review
In one paragraph

Synthesis in Annals of internal medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
105citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

105 citing papers in PubMed, 1 synthesis or guideline pooled it.

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45 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Aaron P MitchellMemorial Sloan Kettering Cancer Center, New York, New York (A.P.M., N.U.T., R.L.G., S.C., S.M.T., L.A.D., D.K.).ORCID 0000-0003-3639-3515
Niti U TrivediMemorial Sloan Kettering Cancer Center, New York, New York (A.P.M., N.U.T., R.L.G., S.C., S.M.T., L.A.D., D.K.).ORCID 0000-0002-3967-6492
Renee L GennarelliMemorial Sloan Kettering Cancer Center, New York, New York (A.P.M., N.U.T., R.L.G., S.C., S.M.T., L.A.D., D.K.).ORCID 0000-0003-2059-7265
Susan ChimonasMemorial Sloan Kettering Cancer Center, New York, New York (A.P.M., N.U.T., R.L.G., S.C., S.M.T., L.A.D., D.K.).ORCID 0000-0002-7742-5950
Sara M TabatabaiMemorial Sloan Kettering Cancer Center, New York, New York (A.P.M., N.U.T., R.L.G., S.C., S.M.T., L.A.D., D.K.).ORCID 0000-0002-5498-7176
Johanna GoldbergMedical Library, Memorial Sloan Kettering Cancer Center, New York, New York (J.G.).ORCID 0000-0003-1913-4722
Luis A DiazMemorial Sloan Kettering Cancer Center, New York, New York (A.P.M., N.U.T., R.L.G., S.C., S.M.T., L.A.D., D.K.).ORCID 0000-0002-7079-8914
Deborah KorensteinMemorial Sloan Kettering Cancer Center, New York, New York (A.P.M., N.U.T., R.L.G., S.C., S.M.T., L.A.D., D.K.).

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Elisa de Stanchina · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

backgroundFinancial payments from the drug industry to U.S. physicians are common. Payments may influence physicians' clinical decision making and drug prescribing. PURPOSE: To evaluate whether receipt of payments from the drug industry is associated with physician prescribing practices. DATA SOURCES: MEDLINE (Ovid), Embase, the Cochrane Library, Web of Science, and EconLit were searched without language restrictions. The search had no limiting start date and concluded on 16 September 2020. STUDY SELECTION: Studies that estimated the association between receipt of industry payments (exposure) and prescribing (outcome). DATA EXTRACTION: Pairs of reviewers extracted the primary analysis or analyses from each study and evaluated risk of bias (ROB). DATA SYNTHESIS: Thirty-six studies comprising 101 analyses were included. Most studies ( LIMITATION: The design was observational, 21 of 36 studies had serious ROB, and publication bias was possible.

conclusionThe association between industry payments and physician prescribing was consistent across all studies that have evaluated this association. Findings regarding a temporal association and dose-response suggest a causal relationship. PRIMARY FUNDING SOURCE: National Cancer Institute.

Indexed as

Drug IndustryPractice Patterns, Physicians'Drug CostsHumans

Identifiers

PMID33226858
PMCPMC8315858

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.