Evidence map›Paper›PMID 33226854›Full record

ReviewExpert opinion on investigational drugs2021

Cholangiocarcinoma: bridging the translational gap from preclinical to clinical development and implications for future therapy.

Leonardo Baiocchi, Keisaku Sato, Burcin Ekser, Lindsey Kennedy, Heather Francis, Ludovica Ceci, Ilaria Lenci, Domenico Alvaro, Antonio Franchitto, Paolo Onori and 5 more

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Expert opinion on investigational drugs, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Moving forward in the treatment of cholangiocarcinoma.World journal of gastrointestinal oncology · 2021
    Review
  8. Article
  9. Patient-Derived Organoids of Cholangiocarcinoma.International journal of molecular sciences · 2021
    Article
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 2 countries.

Leonardo BaiocchiLiver Unit, Department of Medicine, University of Rome Tor Vergata, Rome, Italy.
Keisaku SatoHepatology and Gastroenterology, Medicine, Indiana University, Indianapolis, IN, USA.
Burcin EkserDivision of Transplant Surgery, Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA.
Lindsey KennedyHepatology and Gastroenterology, Medicine, Indiana University, Indianapolis, IN, USA.
Heather FrancisHepatology and Gastroenterology, Medicine, Indiana University, Indianapolis, IN, USA.
Ludovica CeciHepatology and Gastroenterology, Medicine, Indiana University, Indianapolis, IN, USA.
Ilaria LenciLiver Unit, Department of Medicine, University of Rome Tor Vergata, Rome, Italy.
Domenico AlvaroDepartment of Internal Medicine and Medical Specialties, Sapienza University of Rome, Rome, Italy.
Antonio FranchittoEleonora Lorillard Spencer Cenci Foundation, Rome, Italy.
Paolo OnoriDepartment of Anatomical, Histological, Forensic Medicine and Orthopedics Sciences, Sapienza University of Rome, Rome, Italy.
Eugenio GaudioDepartment of Anatomical, Histological, Forensic Medicine and Orthopedics Sciences, Sapienza University of Rome, Rome, Italy.
Chaodong WuDepartment of Nutrition, Texas A&M University, College Station, TX, USA.
Sanjukta ChakrabortyDepartment of Medical Physiology, Texas A&M University, Bryan, TX, USA.
Shannon GlaserDepartment of Medical Physiology, Texas A&M University, Bryan, TX, USA.
Gianfranco AlpiniHepatology and Gastroenterology, Medicine, Indiana University, Indianapolis, IN, USA.
Sapienza University of Rome · ITIndiana University – Purdue University Indianapolis · USBryan College · USRichard L. Roudebush VA Medical Center · USUniversity of Rome Tor Vergata · ITIndiana University School of MedicineTexas A&M University · US

Funding

GROWTH REGULATION OF THE INTRAHEPATIC BILIARY TREER01DK054811 · NIDDK · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI ALPINI, GIANFRANCO D, GLASER, SHANNON STROUD · 2000 to 2021
$3.8M
The Paracrine Regulation of Mast Cells During Biliary/Cholangiocyte Repair and DamageR01DK108959 · NIDDK · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI FRANCIS, HEATHER L · 2016 to 2024
$2.5M
Role of Sensory Neuropeptides in the Regulation of Biliary FunctionR01DK076898 · NIDDK · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI ALPINI, GIANFRANCO D, GLASER, SHANNON STROUD · 2008 to 2016
$1.8M
Mechanisms of mast cell/cholangiocyte regulation of non-alcoholic fatty liver disease progressionR01DK119421 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI FRANCIS, HEATHER L · 2019 to 2022
$1.4M
Neuroendocrine Regulation of Biliary Growth and FibrosisR01DK110035 · NIDDK · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI ALPINI, GIANFRANCO D, GLASER, SHANNON STROUD · 2017 to 2020
$1.2M
Regulation of biliary growth and fibrosis by melatoninR01DK115184 · NIDDK · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI ALPINI, GIANFRANCO D, GLASER, SHANNON STROUD · 2017 to 2020
$1.2M
REGULATION OF CELLULAR SENESCENCE BY NON-CODING RNAS IN ALCOHOLIC LIVER INJURYR21AA025997 · NIAAA · SCOTT AND WHITE MEMORIAL HOSPITAL · PI ALPINI, GIANFRANCO D, MENG, FANYIN · 2017 to 2018
$435k
ShEEP Request for Leica Laser Capture Microdissection System (LMD7)IS1BX005020 · VA · RLR VA MEDICAL CENTER · PI ALPINI, GIANFRANCO D · 2019 to 2019
–
BLR&D Research Career Scientist AwardIK6BX005226 · VA · RLR VA MEDICAL CENTER · PI FRANCIS, HEATHER L · 2020 to 2024
–
BLR&D Research Career Scientist AwardIK6BX004601 · VA · RLR VA MEDICAL CENTER · PI ALPINI, GIANFRANCO D · 2019 to 2025
–
Mechanisms of synergistic regulation of biliary inflammation and fibrosisI01BX003031 · VA · RLR VA MEDICAL CENTER · PI FRANCIS, HEATHER L · 2016 to 2023
–
BLRD VA I01 BX000574BLRD VA I01 BX003031BLRD VA IK6 BX004601BLRD VA IK6 BX005226BLRD VA IS1 BX005020NIAAA NIH HHS R21 AA025997NIDDK NIH HHS R01 DK054811NIDDK NIH HHS R01 DK076898NIDDK NIH HHS R01 DK108959NIDDK NIH HHS R01 DK110035NIDDK NIH HHS R01 DK115184NIDDK NIH HHS R01 DK119421
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Molecular Targeted TherapyAnimalsAntineoplastic AgentsBile Duct NeoplasmsCholangiocarcinomaDrug DevelopmentHumansPrognosisSurvival RateTranslational Research, BiomedicalAntineoplastic AgentsCholangiocarcinomacholangiocyteendocrine regulationpreclinical modeltargeted therapytranslational gap

Identifiers

PMID33226854
PMCPMC8441992
OpenAlexW3107290758

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.