ArticleACS nano2020
Going beyond the Debye Length: Overcoming Charge Screening Limitations in Next-Generation Bioelectronic Sensors.
Article in ACS nano, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
69 citing papers in PubMed, 1 citations in OpenAlex.
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- Discriminating Between Living and Dead Bacteria With a Field-Effect Transistor Based on Nano-Channels.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Bacterial ribonucleoprotein bodies maintain an acidic pH environment as a mechanism of enzyme regulation.Nature communications · 2026Article
- Decoding non-faradaic signal transduction in organic electrochemical transistor based biosensors.Nature communications · 2026Article
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- Practical Applications of 2D Material FET Biosensors: Functionalization Strategies and Detection Performance.Biosensors · 2026Review
- State-of-the-Art Applications of Field-Effect Transistor Biosensors in Exosome Detection: A Comprehensive Review.Biosensors · 2026Review
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- Tri-Layer Solid-State Nanopore Arrays with Crosstalk Suppression for High-Throughput, Femtomolar-Level Biosensing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Graphene-Based Chemical Field-Effect Transistors: Impact of Electric Double Layer Model and Quantum Capacitance on NaMicromachines · 2026Article
- Magnetoelectric Nanoparticle-Based Wireless Brain-Computer Interface: Underlying Physics and Projected Technology Pathway.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Single-Molecule Conductance of Non-Redox Proteins: Mechanisms, Measurements, and Applications.Biomolecules · 2026Review
- Electrochemical Biosensing Platforms for Rapid and Early Diagnosis of Crop Fungal and Viral Diseases.Sensors (Basel, Switzerland) · 2026Review
- Electrically Tunable Optofluidic Metasurface.ACS nano · 2026Article
- Nucleic Acid-Based Field-Effect Transistor Biosensors.Biosensors · 2026Review
- Magnetoelectric Nanotherapy Achieves Complete Tumor Ablation and Prolonged Survival in Pancreatic Cancer Murine Models.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Selective Wettability-Driven Evaporation-Enhanced Redox Cycling for Robust and Ultrasensitive Detection of Viral Particles.Small methods · 2026Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Electronic biosensors are a natural fit for field-deployable diagnostic devices because they can be miniaturized, mass produced, and integrated with circuitry. Unfortunately, progress in the development of such platforms has been hindered by the fact that mobile ions present in biological samples screen charges from the target molecule, greatly reducing sensor sensitivity. Under physiological conditions, the thickness of the resulting electric double layer is less than 1 nm, and it has generally been assumed that electronic detection beyond this distance is virtually impossible. However, a few recently described sensor design strategies seem to defy this conventional wisdom, exploiting the physics of electrical double layers in ways that traditional models do not capture. In the first strategy, charge screening is decreased by constraining the space in which double layers can form. The second strategy uses external stimuli to prevent double layers from reaching equilibrium, thereby effectively reducing charge screening. In this Perspective, we describe these relatively new concepts and offer theoretical insights into mechanisms that may enable electronic biosensing beyond the Debye length. If these concepts can be further developed and translated into practical electronic biosensors, we foresee exciting opportunities for the next generation of diagnostic technologies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.