ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2021
ATN incorporating cerebrospinal fluid neurofilament light chain detects frontotemporal lobar degeneration.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 37 citations in OpenAlex.
- Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy.Annals of clinical and translational neurology · 2026Article
- Risk factors and clinical significance of neurodegenerative co-pathologies in symptomatic cerebral small vessel disease.Journal of neurology · 2025Article
- Beta amyloid PET scans for dementia diagnoses: Practice and research implications from CARE-IDEAS.Journal of the American Geriatrics Society · 2024Article
- Evaluation of a multimodal diagnostic algorithm for prediction of cognitive impairment in elderly patients with dizziness.Journal of neurology · 2024Article
- Plasma proteomic profiles predict future dementia in healthy adults.Nature aging · 2024Article
- Evaluation of ATNNeurology · 2024Article
- Dissociable Effects of Alzheimer's Disease-Related Cognitive Dysfunction and Aging on Functional Brain Network Segregation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Frontotemporal lobar degeneration.Nature reviews. Disease primers · 2023Review
- Tau; One Protein, So Many Diseases.Biology · 2023Review
- Elevated Plasma Phosphorylated Tau 181 in Amyotrophic Lateral Sclerosis.Annals of neurology · 2022Article
- Advances in brain barriers and brain fluids research in 2021: great progress in a time of adversity.Fluids and barriers of the CNS · 2022Article
- Peripheral sTREM2-Related Inflammatory Activity Alterations in Early-Stage Alzheimer's Disease.Journal of immunology (Baltimore, Md. : 1950) · 2022Article
- Tauopathies: new perspectives and challenges.Molecular neurodegeneration · 2022Review
- Development of Alzheimer's Disease Biomarkers: From CSF- to Blood-Based Biomarkers.Biomedicines · 2022Review
- Cerebrospinal Fluid Biomarkers in Autopsy-Confirmed Alzheimer Disease and Frontotemporal Lobar Degeneration.Neurology · 2022Article
- Different AT(N) profiles and clinical progression classified by two different N markers using total tau and neurofilament light chain in cerebrospinal fluid.BMJ neurology open · 2022Article
- Neurofilament Light Chain as Biomarker for Amyotrophic Lateral Sclerosis and Frontotemporal Dementia.Frontiers in neuroscience · 2021Review
- Harmonization and standardization of biofluid-based biomarker measurements for AT(N) classification in Alzheimer's disease.Alzheimer's & dementia (Amsterdam, Netherlands)Review
Corrections and comments
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Authors and funding
14 authors at 2 institutions in 3 countries.
Funding
Abstract
introductionThe ATN framework provides an in vivo diagnosis of Alzheimer's disease (AD) using cerebrospinal fluid (CSF) biomarkers of pathologic amyloid plaques (A), tangles (T), and neurodegeneration (N). ATN is rarely evaluated in pathologically confirmed patients and its poor sensitivity to suspected non-Alzheimer's pathophysiologies (SNAP), including frontotemporal lobar degeneration (FTLD), leads to misdiagnoses. We compared accuracy of ATN (ATN
methodsATN
resultsATN DISCUSSION: ATN
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.