Evidence map›Paper›PMID 33226571›Full record

ArticleMolecular and cellular biochemistry2021

Melatonin upregulates DNA-PKcs to suppress apoptosis of human umbilical vein endothelial cells via inhibiting miR-101 under H

Hao Gu, Jian Li, Rongrong Zhang

Abstract read
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In one paragraph

Article in Molecular and cellular biochemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Hao Gu *Department of Pediatrics, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, No.1 the Yellow River West Road, Huaiyin District, Huai'an, Jiangsu, 223300, People's Republic of China.
Jian Li *Department of Anesthesiology, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu, 223300, People's Republic of China.
Rongrong ZhangDepartment of Pediatrics, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, No.1 the Yellow River West Road, Huaiyin District, Huai'an, Jiangsu, 223300, People's Republic of China. hayyzhrr@njmu.edu.cn.ORCID http://orcid.org/0000-0002-1176-7835
Huaian First People’s Hospital · CNXuzhou Medical College · CN

Funding

Huaian Key Laboratory of Pediatric Respiratory Diagnosis and Treatment HAP201607
6 · The paper itself

Abstract

Melatonin has been implicated in inhibiting oxidative stress-induced apoptosis of endothelial cells. However, the underlying mechanism remains poorly understood. In this study, we examined the effect of melatonin on apoptosis of human umbilical vein endothelial cells (HUVECs) induced by H

Indexed as

Oxidative StressAntioxidantsCells, CulturedDNA-Activated Protein KinaseHumansHuman Umbilical Vein Endothelial CellsHydrogen PeroxideMelatoninMicroRNAsOxidantsPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktSignal TransductionUp-RegulationAKT1 protein, humanAntioxidantsDNA-Activated Protein KinaseHydrogen PeroxideMelatoninMicroRNAsMIRN101 microRNA, humanOxidantsPhosphatidylinositol 3-KinasesPRKDC protein, humanProto-Oncogene Proteins c-aktDNA-PKcsEndothelial cellsMelatoninmiRNA-101Oxidative stress

Identifiers

PMID33226571
OpenAlexW3110308091

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.