Evidence map›Paper›PMID 33226449›Full record

ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2021

Methylprednisolone acetate mitigates IL1β induced changes in matrix metalloproteinase gene expression in skeletally immature ovine explant knee tissues.

Kristen I Barton, May Chung, Cyril B Frank, Nigel G Shrive, David A Hart

Abstract read
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In one paragraph

Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Kristen I BartonOrthopaedic Surgery, Schulich School of Dentistry and Medicine, London Health Sciences Centre, Western University, 1151 Richmond St, London, ON, N6A 5C1, Canada. kbarto@uwo.ca.ORCID http://orcid.org/0000-0002-5143-7822
May ChungMcCaig Institute for Bone and Joint Health, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Cyril B FrankOrthopaedic Surgery, Schulich School of Dentistry and Medicine, London Health Sciences Centre, Western University, 1151 Richmond St, London, ON, N6A 5C1, Canada.
Nigel G ShriveOrthopaedic Surgery, Schulich School of Dentistry and Medicine, London Health Sciences Centre, Western University, 1151 Richmond St, London, ON, N6A 5C1, Canada.
David A HartMcCaig Institute for Bone and Joint Health, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Western University · CAUniversity of Calgary · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

OBJECTIVE AND

designThis study aimed at evaluating the effect of methylprednisolone (MPA) on messenger ribonucleic acid (mRNA) expression levels in immature ovine knee joint tissue explants following interleukin (IL)1β induction and to assess responsiveness of the explants. MATERIAL OR SUBJECTS: Explants were harvested from the articular cartilage, synovium, and infrapatellar fat pad (IPFP) from immature female sheep. TREATMENT: Methylprednisolone.

methodsThe samples were allocated into six groups: (1) control, (2) MPA (10

resultsMethylprednisolone treatment significantly suppressed MMPs consistently across the cartilage (MMP1, MMP3, and MMP13), synovium (MMP1 and MMP3), and IPFP (MMP13) (all p < 0.05). Other genes that were less consistently suppressed include endogenous IL1β (cartilage) and IL6 (IPFP) (all p < 0.05), and others not affected either by IL-1 exposure or subsequent MPA include TGFβ1, TLR4, and adipose-related molecules.

conclusionsMethylprednisolone significantly mitigated IL1β induced mRNA expression for MMPs in the immature cartilage, synovium, and IPFP, but the extent of the responsiveness was tissue-, location-, and gene-specific.

Indexed as

Interleukin-1betaAnimalsAnti-Inflammatory AgentsCartilage, ArticularCell SurvivalCytokinesFemaleGene ExpressionKnee JointMatrix MetalloproteinasesMethylprednisolone AcetateRNA, MessengerSheepSynovial MembraneAnti-Inflammatory AgentsCytokinesInterleukin-1betaMatrix MetalloproteinasesMethylprednisolone AcetateRNA, MessengerArticular cartilageExplant culturesGlucocorticoidInfrapatellar fat padMethylprednisolone acetateSynovium

Identifiers

PMID33226449
OpenAlexW3108368795

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.